INHIBITION OF PROSTAGLANDIN AND LEUKOTRIENE BIOSYNTHESIS BY GINGEROLS AND DIARYLHEPTANOIDS.

Title	INHIBITION OF PROSTAGLANDIN AND LEUKOTRIENE BIOSYNTHESIS BY GINGEROLS AND DIARYLHEPTANOIDS.
Authors	KIUCHI,F: IWAKAMI,S: SHIBUYA,M: HANAOKA,F: SANKAWA,U:
Year	1992
Volume	40
Issue	2

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	PROSTAGLANDIN SYNTHETASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	GINGEROL,2:	INACTIVE
2	LIPOXYGENASE,5: INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	GINGEROL,2:	ACTIVE

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	PROSTAGLANDIN SYNTHETASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	GINGEROL,4:	ACTIVE
2	LIPOXYGENASE,5: INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	GINGEROL,4:	ACTIVE

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	PROSTAGLANDIN SYNTHETASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	GINGEROL,8:	ACTIVE
2	LIPOXYGENASE,5: INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	GINGEROL,8:	ACTIVE

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	PROSTAGLANDIN SYNTHETASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	GINGEROL,12:	ACTIVE
2	LIPOXYGENASE,5: INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	GINGEROL,12:	STRONG ACTIVITY

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	PROSTAGLANDIN SYNTHETASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	GINGEROL,14:	ACTIVE
2	LIPOXYGENASE,5: INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	GINGEROL,14:	STRONG ACTIVITY

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	PROSTAGLANDIN SYNTHETASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	GINGEROL,16:	ACTIVE
2	LIPOXYGENASE,5: INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	GINGEROL,16:	STRONG ACTIVITY

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	PROSTAGLANDIN SYNTHETASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	GINGEROL,6: METHYL:	ACTIVE

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	PROSTAGLANDIN SYNTHETASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	GINGEROL,6: DIACETYL:	ACTIVE

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	PROSTAGLANDIN SYNTHETASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	YAKUCHINONE A	ACTIVE
2	LIPOXYGENASE,5: INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	YAKUCHINONE A	ACTIVE
3	LIPOXYGENASE,5: INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	HEPTAN-3-ONE,5-HYDROXY-7-(4''-HYDROXY-PHENYL)-1-(3'-4'-DIHYDROXY-PHENYL):	ACTIVE
4	PROSTAGLANDIN SYNTHETASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	HEPTAN-3-ONE,7-PHENYL-1-(3'-METHOXY-4'-ACETOXY-PHENYL):	ACTIVE
5	LIPOXYGENASE,5: INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	HEPTAN-3-ONE,7-PHENYL-1-(3'-METHOXY-4'-ACETOXY-PHENYL):	ACTIVE
6	PROSTAGLANDIN SYNTHETASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	HEPTAN-3-ONE,7-PHENYL-1-(3'-4'-DIMETHOXY-PHENYL):	INACTIVE
7	LIPOXYGENASE,5: INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	HEPTAN-3-ONE,7-(4''-HYDROXY-3''-METHOXY-PHENYL)-1-PHENYL:	ACTIVE
8	PROSTAGLANDIN SYNTHETASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	HEPTAN-3-ONE,5-HYDROXY-7-PHENYL-1-(4'-HYDROXY-3'-METHOXY-PHENYL):	ACTIVE
9	LIPOXYGENASE,5: INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	HEPTAN-3-ONE,5-HYDROXY-7-PHENYL-1-(4'-HYDROXY-3'-METHOXY-PHENYL):	ACTIVE
10	LIPOXYGENASE,5: INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	HEPTAN-3-ONE,5-HYDROXY-7-PHENYL-1-(3'-HYDROXY-4'-METHOXY-PHENYL):	INACTIVE
11	LIPOXYGENASE,5: INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	HEPTAN-3-ONE,5-HYDROXY-7-PHENYL-1-(4'-HYDROXY-PHENYL):	INACTIVE
12	LIPOXYGENASE,5: INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	HEPTAN-3-ONE,5-HYDROXY-7-PHENYL-1-(3'-4'-DIHYDROXY):	ACTIVE
13	LIPOXYGENASE,5: INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	HEPTAN-3-OL,7-(4''-HYDROXY-3''-METHOXY-PHENYL)-1-PHENYL:	ACTIVE

Zingiber officinale (ZINGIBERACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	UV SPECTRUM GIVEN FORISOLATION AND IDENTIFICATION OFMASS-SPECTRAL FRAGMENTATION REPORTEDPMR SPECTRUM REPORTEDINFRARED SPECTRUM REPORTED FORQUANTITATIVE DATA	GINGERDIONE,6: DEHYDRO:	None
2	PROSTAGLANDIN SYNTHETASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	GINGERDIONE,6: DEHYDRO:	ACTIVE
3	Not specified	UV SPECTRUM GIVEN FORISOLATION AND IDENTIFICATION OFMASS-SPECTRAL FRAGMENTATION REPORTEDPMR SPECTRUM REPORTEDINFRARED SPECTRUM REPORTED FORQUANTITATIVE DATA	GINGERDIONE,10-DIHYDRO:	None
4	Not specified	UV SPECTRUM GIVEN FORISOLATION AND IDENTIFICATION OFMASS-SPECTRAL FRAGMENTATION REPORTEDPMR SPECTRUM REPORTEDINFRARED SPECTRUM REPORTED FORQUANTITATIVE DATA	GINGERDIONE,6:	None
5	PROSTAGLANDIN SYNTHETASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	GINGERDIONE,10-DIHYDRO:	ACTIVE
6	PROSTAGLANDIN SYNTHETASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	GINGERDIONE,6:	ACTIVE
7	Not specified	UV SPECTRUM GIVEN FORISOLATION AND IDENTIFICATION OFPMR SPECTRUM REPORTEDINFRARED SPECTRUM REPORTED FORQUANTITATIVE DATA	GINGERDIONE,10:	None
8	Not specified	ISOLATION AND IDENTIFICATION OFQUANTITATIVE DATA	GINGEROL,6:	None
9	PROSTAGLANDIN SYNTHETASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	GINGERDIONE,10:	ACTIVE
10	PROSTAGLANDIN SYNTHETASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	GINGEROL,6:	ACTIVE
11	Not specified	ISOLATION AND IDENTIFICATION OFQUANTITATIVE DATA	GINGEDIOL,6: DIACETATE	None
12	Not specified	ISOLATION AND IDENTIFICATION OFQUANTITATIVE DATA	GINGEROL,6: ACETYL:	None
13	PROSTAGLANDIN SYNTHETASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	GINGEDIOL,6: DIACETATE	ACTIVE
14	PROSTAGLANDIN SYNTHETASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	GINGEROL,6: ACETYL:	ACTIVE
15	Not specified	ISOLATION AND IDENTIFICATION OFQUANTITATIVE DATA	GINGEDIOL,6:	None
16	Not specified	ISOLATION AND IDENTIFICATION OFQUANTITATIVE DATA	GINGEROL,10:	None
17	PROSTAGLANDIN SYNTHETASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	GINGEROL,10:	ACTIVE
18	PROSTAGLANDIN SYNTHETASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	GINGEROL,10:	ACTIVE
19	LIPOXYGENASE,5: INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	GINGEROL,10:	ACTIVE
20	Not specified	ISOLATION AND IDENTIFICATION OFQUANTITATIVE DATA	CURCUMIN,HEXAHYDRO:	None
21	Not specified	ISOLATION AND IDENTIFICATION OF	SHOGAOL,6:	None
22	PROSTAGLANDIN SYNTHETASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CURCUMIN,HEXAHYDRO:	ACTIVE
23	LIPOXYGENASE,5: INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CURCUMIN,HEXAHYDRO:	ACTIVE
24	PROSTAGLANDIN SYNTHETASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SHOGAOL,6:	ACTIVE

Alpinia officinarum (ZINGIBERACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	ISOLATION AND IDENTIFICATION OFQUANTITATIVE DATA	HEPT-4-EN-3-ONE,7-(4''-HYDROXY-3''-METHOXY-PHENYL)-1-PHENYL:	None
2	PROSTAGLANDIN SYNTHETASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	HEPT-4-EN-3-ONE,7-(4''-HYDROXY-3''-METHOXY-PHENYL)-1-PHENYL:	ACTIVE
3	Not specified	ISOLATION AND IDENTIFICATION OFQUANTITATIVE DATA	HEPTAN-3-ONE,5-HYDROXY-1-7-DIPHENYL:	None
4	Not specified	ISOLATION AND IDENTIFICATION OFQUANTITATIVE DATA	HEPTAN-3-ONE,5-HYDROXY-7-(4''-HYDROXY-3''-METHOXY-PHENYL)-1-PHENYL:	None
5	PROSTAGLANDIN SYNTHETASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	HEPTAN-3-ONE,5-HYDROXY-1-7-DIPHENYL:	ACTIVE
6	PROSTAGLANDIN SYNTHETASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	HEPTAN-3-ONE,5-HYDROXY-7-(4''-HYDROXY-3''-METHOXY-PHENYL)-1-PHENYL:	ACTIVE
7	LIPOXYGENASE,5: INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	HEPTAN-3-ONE,5-HYDROXY-7-(4''-HYDROXY-3''-METHOXY-PHENYL)-1-PHENYL:	ACTIVE
8	Not specified	MASS-SPECTRAL FRAGMENTATION REPORTEDPMR SPECTRUM REPORTEDINFRARED SPECTRUM REPORTED FORQUANTITATIVE DATAISOLATION OF A COMPOUND WITH NOVEL STRUCTURE	HEPT-3-5-DIONE,7(4''-HYDROXY-3'-METHOXY-PHENYL)-PHENYL:	None
9	Not specified	MASS-SPECTRAL FRAGMENTATION REPORTEDPMR SPECTRUM REPORTEDINFRARED SPECTRUM REPORTED FORQUANTITATIVE DATAISOLATION OF A COMPOUND WITH NOVEL STRUCTURE	HEPTAN-3-ONE,5-METHOXY-7-(4'-HYDROXY-3''-METHOXY-PHENYL)-1-PHENYL:	None
10	PROSTAGLANDIN SYNTHETASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	HEPT-3-5-DIONE,7(4''-HYDROXY-3'-METHOXY-PHENYL)-PHENYL:	ACTIVE
11	PROSTAGLANDIN SYNTHETASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	HEPTAN-3-ONE,5-METHOXY-7-(4'-HYDROXY-3''-METHOXY-PHENYL)-1-PHENYL:	ACTIVE
12	Not specified	MASS-SPECTRAL FRAGMENTATION REPORTEDPMR SPECTRUM REPORTEDINFRARED SPECTRUM REPORTED FORQUANTITATIVE DATAISOLATION OF A COMPOUND WITH NOVEL STRUCTURE	HEPTAN-3-ONE,5-HYDROXY-7-(4''-HYDROXY-PHENYL)-1-PHENYL:	None
13	PROSTAGLANDIN SYNTHETASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	HEPTAN-3-ONE,5-HYDROXY-7-(4''-HYDROXY-PHENYL)-1-PHENYL:	ACTIVE
14	Not specified	ISOLATION AND IDENTIFICATION OF	GALANGIN	None
15	Not specified	ISOLATION AND IDENTIFICATION OF	IZALPIN	None
16	Not specified	ISOLATION AND IDENTIFICATION OF	KAEMPFERIDE	None
17	Not specified	ISOLATION AND IDENTIFICATION OF	KAEMPFEROL	None

Citation 114228

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Organisms and Their Experiments (11)

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Zingiber officinale (ZINGIBERACEAE)

Alpinia officinarum (ZINGIBERACEAE)

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