PROTEASE INHIBITORS PRODUCED BY MICROORGANISMS.

Title	PROTEASE INHIBITORS PRODUCED BY MICROORGANISMS.
Authors	UMEZAWA,H: AOYAGI,T: ISHIZUKA,M: TAKEUCHI,T:
Year	1979
Volume	70
Issue

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	CARCINOGENESIS INHIBITION	PHARMACOLOGY OF COMPOUND - IN VIVO	LEUPEPTIN	ACTIVE
2	CARCINOGENESIS INHIBITION	PHARMACOLOGY OF COMPOUND - IN VIVO	LEUPEPTIN	ACTIVE
3	TOXICITY ASSESSMENT(QUANTITATIVE)	PHARMACOLOGY OF COMPOUND - IN VIVO	LEUPEPTIN	.
4	TOXICITY ASSESSMENT(QUANTITATIVE)	PHARMACOLOGY OF COMPOUND - IN VIVO	LEUPEPTIN	.
5	TOXICITY ASSESSMENT(QUANTITATIVE)	PHARMACOLOGY OF COMPOUND - IN VIVO	LEUPEPTIN	.
6	TOXICITY ASSESSMENT(QUANTITATIVE)	PHARMACOLOGY OF COMPOUND - IN VIVO	LEUPEPTIN	.
7	TOXICITY ASSESSMENT(QUANTITATIVE)	PHARMACOLOGY OF COMPOUND - IN VIVO	LEUPEPTIN	.
8	TOXICITY ASSESSMENT(QUANTITATIVE)	PHARMACOLOGY OF COMPOUND - IN VIVO	LEUPEPTIN	.
9	TOXICITY ASSESSMENT(QUANTITATIVE)	PHARMACOLOGY OF COMPOUND - IN VIVO	LEUPEPTIN	.
10	TOXICITY ASSESSMENT(QUANTITATIVE)	PHARMACOLOGY OF COMPOUND - IN VIVO	LEUPEPTIN	.
11	TOXICITY ASSESSMENT(QUANTITATIVE)	PHARMACOLOGY OF COMPOUND - IN VIVO	LEUPEPTIN	.
12	ANTICOAGULANT ACTIVITY	PHARMACOLOGY OF COMPOUND - IN HUMANS	LEUPEPTIN	ACTIVE
13	ANTICOAGULANT ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVO	LEUPEPTIN	ACTIVE
14	ANTICOAGULANT ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVO	LEUPEPTIN	INACTIVE
15	ANTICOAGULANT ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVO	LEUPEPTIN	INACTIVE
16	ANTICOAGULANT ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVO	LEUPEPTIN	INACTIVE
17	ANTIBURN EFFECT	PHARMACOLOGY OF COMPOUND - IN HUMANS	LEUPEPTIN	ACTIVE
18	ANTIINFLAMMATORY ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVO	LEUPEPTIN	ACTIVE
19	TOXIC EFFECT(GENERAL)	PHARMACOLOGY OF COMPOUND - IN VIVO	LEUPEPTIN	INACTIVE
20	HYPOTENSIVE ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVO	LEUPEPTIN	ACTIVE

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	CARCINOGENESIS INHIBITION	PHARMACOLOGY OF COMPOUND - IN VIVO	ANTIPAIN	ACTIVE
2	ANTICOAGULANT ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVO	ANTIPAIN	ACTIVE
3	TOXIC EFFECT(GENERAL)	PHARMACOLOGY OF COMPOUND - IN VIVO	ANTIPAIN	INACTIVE
4	TOXIC EFFECT(GENERAL)	PHARMACOLOGY OF COMPOUND - IN VIVO	ANTIPAIN	INACTIVE
5	CATHEPSIN B INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	ANTIPAIN	ACTIVE
6	ANTIINFLAMMATORY ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVO	ANTIPAIN	ACTIVE
7	ANTICOAGULANT ACTIVITY	PHARMACOLOGY OF COMPOUND - IN HUMANS	ANTIPAIN	ACTIVE
8	PAPAIN INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	ANTIPAIN	ACTIVE
9	TRYPSIN INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	ANTIPAIN	ACTIVE
10	CATHEPSIN A INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	ANTIPAIN	ACTIVE

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	CHYMOTRYPSIN INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CHYMOSTATIN A	ACTIVE
2	TRYPSIN INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CHYMOSTATIN A	INACTIVE
3	PAPAIN INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CHYMOSTATIN A	WEAK ACTIVITY
4	ANTIINFLAMMATORY ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVO	CHYMOSTATIN A	ACTIVE

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	CHYMOTRYPSIN INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CHYMOSTATIN B	ACTIVE
2	TRYPSIN INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CHYMOSTATIN B	INACTIVE
3	PAPAIN INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CHYMOSTATIN B	WEAK ACTIVITY
4	ANTIINFLAMMATORY ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVO	CHYMOSTATIN B	ACTIVE

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	CHYMOTRYPSIN INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CHYMOSTATIN C	ACTIVE
2	TRYPSIN INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CHYMOSTATIN C	INACTIVE
3	PAPAIN INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CHYMOSTATIN C	WEAK ACTIVITY
4	ANTIINFLAMMATORY ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVO	CHYMOSTATIN C	ACTIVE

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	ELASTASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	ELASTATINAL	ACTIVE
2	TOXIC EFFECT(GENERAL)	PHARMACOLOGY OF COMPOUND - IN VIVO	ELASTATINAL	INACTIVE
3	ANTIINFLAMMATORY ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVO	ELASTATINAL	ACTIVE
4	ANTIMUTAGENIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	ELASTATINAL	ACTIVE

Streptomyces testaceus (STREPTOMYCETACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	ISOLATION AND IDENTIFICATION OF	PEPSTATIN	None
2	PEPSIN INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PEPSTATIN	ACTIVE
3	CATHEPSIN D INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PEPSTATIN	ACTIVE
4	RENIN INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PEPSTATIN	ACTIVE

Streptomyces testaceus (STREPTOMYCETACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	ISOLATION AND IDENTIFICATION OF	PEPSTANONE	None
2	PEPSIN INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PEPSTANONE	ACTIVE
3	CATHEPSIN D INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PEPSTANONE	ACTIVE
4	RENIN INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PEPSTANONE	WEAK ACTIVITY

Streptomyces testaceus (STREPTOMYCETACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	ISOLATION AND IDENTIFICATION OF	PEPSTATIN,HYDROXY:	None
2	PEPSIN INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PEPSTATIN,HYDROXY:	ACTIVE
3	CATHEPSIN D INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PEPSTATIN,HYDROXY:	ACTIVE
4	RENIN INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PEPSTATIN,HYDROXY:	WEAK ACTIVITY

Streptomyces parvisporogenes (STREPTOMYCETACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	ISOLATION AND IDENTIFICATION OF	PEPSTATIN	None
2	PEPSIN INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PEPSTATIN	ACTIVE
3	CATHEPSIN D INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PEPSTATIN	ACTIVE
4	RENIN INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PEPSTATIN	ACTIVE
5	TOXICITY ASSESSMENT(QUANTITATIVE)	PHARMACOLOGY OF COMPOUND - IN VIVO	PEPSTATIN	.
6	TOXICITY ASSESSMENT(QUANTITATIVE)	PHARMACOLOGY OF COMPOUND - IN VIVO	PEPSTATIN	.
7	TOXICITY ASSESSMENT(QUANTITATIVE)	PHARMACOLOGY OF COMPOUND - IN VIVO	PEPSTATIN	.
8	TOXIC EFFECT(GENERAL)	PHARMACOLOGY OF COMPOUND - IN VIVO	PEPSTATIN	INACTIVE
9	TOXIC EFFECT(GENERAL)	PHARMACOLOGY OF COMPOUND - IN VIVO	PEPSTATIN	INACTIVE

Streptomyces species (STREPTOMYCETACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	ISOLATION AND IDENTIFICATION OF	PHOSPHORAMIDON	None
2	TOXICITY ASSESSMENT(QUANTITATIVE)	PHARMACOLOGY OF COMPOUND - IN VIVO	PHOSPHORAMIDON	.
3	THERMOLYSIN INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PHOSPHORAMIDON	ACTIVE

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	ENDOPEPTIDASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	BESTATIN	INACTIVE
2	AMINOPEPTIDASE A INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	BESTATIN	INACTIVE
3	LEUCINE AMINOPEPTIDASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	BESTATIN	ACTIVE
4	AMINOPEPTIDASE B INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	BESTATIN	ACTIVE
5	DELAYED TYPE CUTANEOUS HYPERSENSITIVITY STIMULATION	PHARMACOLOGY OF COMPOUND - IN VIVO	BESTATIN	ACTIVE
6	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVOANTICANCER AND/OR CYTOTOXICITY MARKER CODE	BESTATIN	ACTIVE
7	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVOANTICANCER AND/OR CYTOTOXICITY MARKER CODE	BESTATIN	ACTIVE
8	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVOANTICANCER AND/OR CYTOTOXICITY MARKER CODE	BESTATIN	ACTIVE
9	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVOANTICANCER AND/OR CYTOTOXICITY MARKER CODE	BESTATIN	ACTIVE
10	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVOANTICANCER AND/OR CYTOTOXICITY MARKER CODE	BESTATIN	ACTIVE
11	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVOANTICANCER AND/OR CYTOTOXICITY MARKER CODE	BESTATIN	ACTIVE

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVOANTICANCER AND/OR CYTOTOXICITY MARKER CODE	MACROMOMYCIN	ACTIVE

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	AMINOPEPTIDASE A INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	AMASTATIN	ACTIVE

Citation 117268

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Organisms and Their Experiments (14)

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Streptomyces testaceus (STREPTOMYCETACEAE)

Streptomyces testaceus (STREPTOMYCETACEAE)

Streptomyces testaceus (STREPTOMYCETACEAE)

Streptomyces parvisporogenes (STREPTOMYCETACEAE)

Streptomyces species (STREPTOMYCETACEAE)

Unknown organism

Unknown organism

Unknown organism

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