Citation 129959

OKADA,Y: MIYAUCHI,N: SUZUKI,K: KOBAYASHI,T: TSUTSUI,C: MAYUZUMI,K: NISHIBE,S: OKUYAMA,T:. (1995). SEARCH FOR NATURALLY OCCURRING SUBSTANCES TO PREVENT THE COMPLICATIONS OF DIABETES. II. INHIBITORY EFFECT OF COUMARIN AND FLAVONOID DERIVATIVES ON BOVINE LENS ALDOSE REDUCTASE AND RABBIT PLATELET AGGREGATION.. 43(8)

Citation Details

Title	SEARCH FOR NATURALLY OCCURRING SUBSTANCES TO PREVENT THE COMPLICATIONS OF DIABETES. II. INHIBITORY EFFECT OF COUMARIN AND FLAVONOID DERIVATIVES ON BOVINE LENS ALDOSE REDUCTASE AND RABBIT PLATELET AGGREGATION.
Authors	OKADA,Y: MIYAUCHI,N: SUZUKI,K: KOBAYASHI,T: TSUTSUI,C: MAYUZUMI,K: NISHIBE,S: OKUYAMA,T:
Year	1995
Volume	43
Issue	8

Summary

Year: 1995

Journal: Unknown

Organisms and Their Experiments (6)

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	ALDOSE REDUCTASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN	WEAK ACTIVITY
2	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN	ACTIVE
3	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN	ACTIVE
4	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN	ACTIVE
5	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN	ACTIVE
6	ALDOSE REDUCTASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SCOPOLETIN,ISO:	WEAK ACTIVITY
7	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SCOPOLETIN,ISO:	ACTIVE
8	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SCOPOLETIN,ISO:	ACTIVE
9	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SCOPOLETIN,ISO:	ACTIVE
10	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SCOPOLETIN,ISO:FRAXIDIN,ISO:	ACTIVE
11	ALDOSE REDUCTASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	FRAXIDIN,ISO:	WEAK ACTIVITY
12	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	FRAXIDIN,ISO:	WEAK ACTIVITY
13	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	FRAXIDIN,ISO:	WEAK ACTIVITY
14	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	FRAXIDIN,ISO:	ACTIVE
15	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	FRAXIDIN,ISO:	ACTIVE
16	ALDOSE REDUCTASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,4-HYDROXY:	ACTIVE
17	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,4-HYDROXY:	ACTIVE
18	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,4-HYDROXY:	ACTIVE
19	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,4-HYDROXY:	ACTIVE
20	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,4-HYDROXY:	ACTIVE
21	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	UMBELLIFERONE	ACTIVE
22	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	UMBELLIFERONE	ACTIVE
23	ALDOSE REDUCTASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	UMBELLIFERONE	ACTIVE
24	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	UMBELLIFERONE	ACTIVE
25	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	UMBELLIFERONE	ACTIVE
26	ALDOSE REDUCTASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	AESCULETIN	ACTIVE
27	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	AESCULETIN	ACTIVE
28	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	AESCULETIN	ACTIVE
29	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	AESCULETIN	ACTIVE
30	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	AESCULETIN	ACTIVE
31	ALDOSE REDUCTASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,4-METHOXY:	ACTIVE
32	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,4-METHOXY:	ACTIVE
33	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,4-METHOXY:	ACTIVE
34	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,4-METHOXY:	ACTIVE
35	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,4-METHOXY:	ACTIVE
36	ALDOSE REDUCTASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	HERNIARIN	WEAK ACTIVITY
37	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	HERNIARIN	ACTIVE
38	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	HERNIARIN	WEAK ACTIVITY
39	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	HERNIARIN	ACTIVE
40	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	HERNIARIN	ACTIVE
41	ALDOSE REDUCTASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CITROPTEN	ACTIVE
42	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CITROPTEN	ACTIVE
43	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CITROPTEN	ACTIVE
44	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CITROPTEN	ACTIVE
45	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CITROPTEN	ACTIVE
46	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,7-ACETOXY-6-METHOXY:	ACTIVE
47	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,7-ACETOXY-6-METHOXY:	ACTIVE
48	ALDOSE REDUCTASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,7-ACETOXY-6-METHOXY:	WEAK ACTIVITY
49	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,7-ACETOXY-6-METHOXY:	ACTIVE
50	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,7-ACETOXY-6-METHOXY:	INACTIVE
51	ALDOSE REDUCTASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,7-ACETOXY:	INACTIVE
52	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,7-ACETOXY:	ACTIVE
53	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,7-ACETOXY:	ACTIVE
54	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,7-ACETOXY:	ACTIVE
55	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,7-ACETOXY:	ACTIVE
56	ALDOSE REDUCTASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,6-7-DIACETOXY:	WEAK ACTIVITY
57	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,6-7-DIACETOXY:	INACTIVE
58	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,6-7-DIACETOXY:	INACTIVE
59	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,6-7-DIACETOXY:	ACTIVE
60	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,6-7-DIACETOXY:	ACTIVE
61	ALDOSE REDUCTASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	AESCULIN	ACTIVE
62	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	AESCULIN	ACTIVE
63	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	AESCULIN	INACTIVE
64	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	AESCULIN	WEAK ACTIVITY
65	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	AESCULIN	WEAK ACTIVITY

Artemisia capillaris (ASTERACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	ISOLATION AND IDENTIFICATION OFQUANTITATIVE DATA	SCOPARONE	None
2	ALDOSE REDUCTASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SCOPARONE	ACTIVE
3	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SCOPARONE	ACTIVE
4	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SCOPARONE	ACTIVE
5	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SCOPARONE	ACTIVE
6	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SCOPARONE	ACTIVE
7	Not specified	ISOLATION AND IDENTIFICATION OFQUANTITATIVE DATA	SCOPOLETIN	None
8	ALDOSE REDUCTASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SCOPOLETIN	ACTIVE
9	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SCOPOLETIN	ACTIVE
10	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SCOPOLETIN	ACTIVE
11	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SCOPOLETIN	ACTIVE
12	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SCOPOLETIN	ACTIVE
13	Not specified	ISOLATION AND IDENTIFICATION OFQUANTITATIVE DATA	CAPILLARISIN	None
14	ALDOSE REDUCTASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CAPILLARISIN	ACTIVE
15	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CAPILLARISIN	ACTIVE
16	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CAPILLARISIN	INACTIVE
17	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CAPILLARISIN	ACTIVE
18	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CAPILLARISIN	INACTIVE
19	Not specified	ISOLATION AND IDENTIFICATION OFQUANTITATIVE DATA	CIRSIMARITIN	None
20	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CIRSIMARITIN	INACTIVE
21	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CIRSIMARITIN	ACTIVE
22	ALDOSE REDUCTASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CIRSIMARITIN	ACTIVE
23	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CIRSIMARITIN	INACTIVE
24	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CIRSIMARITIN	INACTIVE
25	Not specified	ISOLATION AND IDENTIFICATION OFQUANTITATIVE DATA	RHAMNOCITRIN	None
26	ALDOSE REDUCTASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	RHAMNOCITRIN	ACTIVE
27	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	RHAMNOCITRIN	INACTIVE
28	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	RHAMNOCITRIN	INACTIVE
29	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	RHAMNOCITRIN	ACTIVE
30	ADRENERGIC RECEPTOR BLOCKER(ALPHA-1)	PHARMACOLOGY OF COMPOUND - IN VITRO	RHAMNOCITRIN	ACTIVE

Fraxinus japonica (OLEACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	ISOLATION AND IDENTIFICATION OF	FRAXINOL	None
2	ALDOSE REDUCTASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	FRAXINOL	ACTIVE
3	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	FRAXINOL	ACTIVE
4	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	FRAXINOL	ACTIVE
5	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	FRAXINOL	ACTIVE
6	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	FRAXINOL	ACTIVE
7	Not specified	ISOLATION AND IDENTIFICATION OF	MANDSHURIN	None
8	ALDOSE REDUCTASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	MANDSHURIN	WEAK ACTIVITY
9	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	MANDSHURIN	INACTIVE
10	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	MANDSHURIN	INACTIVE
11	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	MANDSHURIN	INACTIVE
12	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	MANDSHURIN	INACTIVE

Eleutherococcus senticosus (ARALIACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	ISOLATION AND IDENTIFICATION OF	SYRINGIN	None
2	ALDOSE REDUCTASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SYRINGIN	EQUIVOCAL
3	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SYRINGIN	INACTIVE
4	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SYRINGIN	INACTIVE
5	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SYRINGIN	INACTIVE
6	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SYRINGIN	INACTIVE

Fraxinus japonica (OLEACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	ISOLATION AND IDENTIFICATION OF	FRAXIN	None
2	ALDOSE REDUCTASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	FRAXIN	ACTIVE
3	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	FRAXIN	ACTIVE
4	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	FRAXIN	WEAK ACTIVITY
5	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	FRAXIN	INACTIVE
6	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	FRAXIN	INACTIVE

Syneilesis aconitifolia (ASTERACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	ISOLATION AND IDENTIFICATION OF	QUERCETIN	None
2	ALDOSE REDUCTASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	QUERCETIN	ACTIVE
3	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	QUERCETIN	ACTIVE
4	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	QUERCETIN	ACTIVE
5	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	QUERCETIN	ACTIVE
6	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	QUERCETIN	ACTIVE
7	Not specified	ISOLATION AND IDENTIFICATION OF	QUERCITRIN	None
8	ALDOSE REDUCTASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	QUERCITRIN	ACTIVE
9	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	QUERCITRIN	WEAK ACTIVITY
10	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	QUERCITRIN	ACTIVE
11	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	QUERCITRIN	ACTIVE
12	PLATELET AGGREGATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	QUERCITRIN	INACTIVE

Citation 129959

Citation Details

Summary

Organisms and Their Experiments (6)

Unknown organism

Artemisia capillaris (ASTERACEAE)

Fraxinus japonica (OLEACEAE)

Eleutherococcus senticosus (ARALIACEAE)

Fraxinus japonica (OLEACEAE)

Syneilesis aconitifolia (ASTERACEAE)

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