ANTIMALARIAL ACTIVITY OF TROPICAL MELIACEAE EXTRACTS AND GEDUNIN DERIVATIVES.

Title	ANTIMALARIAL ACTIVITY OF TROPICAL MELIACEAE EXTRACTS AND GEDUNIN DERIVATIVES.
Authors	MAC KINNON,S: DURST,T: ARNASON,JT: ANGERHOFER,CJ: PEZZUTO,JM: SANCHEZ-VINDAS,PE: POVEDA,LJ: GBEASSOR,M:
Year	1997
Volume	60
Issue	4

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	COMPLETE SYNTHESIS REPORTEDMASS-SPECTRAL FRAGMENTATION REPORTEDPMR SPECTRUM REPORTEDCMR SPECTRUM REPORTEDINFRARED SPECTRUM REPORTED FOR	GEDUNIN,TETRAAHYDRO:	None
2	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	GEDUNIN,TETRAAHYDRO:	ACTIVE
3	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	GEDUNIN,TETRAAHYDRO:	ACTIVE
4	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	GEDUNIN,TETRAAHYDRO:	INACTIVE
5	Not specified	COMPLETE SYNTHESIS REPORTEDMASS-SPECTRAL FRAGMENTATION REPORTEDPMR SPECTRUM REPORTEDCMR SPECTRUM REPORTEDINFRARED SPECTRUM REPORTED FOR	GEDUNIN,21-ACETYL:	None
6	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	GEDUNIN,21-ACETYL:	STRONG ACTIVITY
7	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	GEDUNIN,21-ACETYL:	STRONG ACTIVITY
8	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	GEDUNIN,21-ACETYL:	WEAK ACTIVITY
9	Not specified	COMPLETE SYNTHESIS REPORTEDMASS-SPECTRAL FRAGMENTATION REPORTEDPMR SPECTRUM REPORTEDCMR SPECTRUM REPORTEDINFRARED SPECTRUM REPORTED FOR	GEDUNIN,23-ACETYL:	None
10	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	GEDUNIN,23-ACETYL:	STRONG ACTIVITY
11	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	GEDUNIN,23-ACETYL:	STRONG ACTIVITY
12	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	GEDUNIN,23-ACETYL:	WEAK ACTIVITY
13	Not specified	COMPLETE SYNTHESIS REPORTEDPMR SPECTRUM REPORTEDCMR SPECTRUM REPORTEDINFRARED SPECTRUM REPORTED FOR	GEDUNIN,HEXAHYDRO:	None
14	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	GEDUNIN,HEXAHYDRO:	INACTIVE
15	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	GEDUNIN,HEXAHYDRO:	ACTIVE
16	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	GEDUNIN,HEXAHYDRO:	INACTIVE
17	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	HIRTIN	STRONG ACTIVITY
18	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	HIRTIN	STRONG ACTIVITY
19	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	HIRTIN	ACTIVE
20	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	GEDUNIN,1-2-DIHYDRO:	INACTIVE
21	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	GEDUNIN,1-2-DIHYDRO:	ACTIVE
22	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	GEDUNIN,1-2-DIHYDRO:	INACTIVE
23	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	GEDUNIN,1-2-EPOXY:	ACTIVE
24	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	GEDUNIN,1-2-EPOXY:	ACTIVE
25	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	GEDUNIN,1-2-EPOXY:	INACTIVE
26	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	GEDUNOL,3-BETA: 1-2-DIHYDRO:	ACTIVE
27	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	GEDUNOL,3-BETA: 1-2-DIHYDRO:	ACTIVE
28	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	GEDUNOL,3-BETA: 1-2-DIHYDRO:	INACTIVE
29	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	GEDUNIN,7-DEACETYL:	ACTIVE
30	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	GEDUNIN,7-DEACETYL:	ACTIVE
31	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	GEDUNIN,7-DEACETYL:	INACTIVE
32	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	GEDUNIN,7-KETO:	INACTIVE
33	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	GEDUNIN,7-KETO:	INACTIVE
34	BACTERIAL STIMULANT ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	GEDUNIN,7-KETO:	INACTIVE
35	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	QUININE	ACTIVE
36	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	QUININE	ACTIVE
37	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	ARTEMISININ	STRONG ACTIVITY
38	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	ARTEMISININ	STRONG ACTIVITY

Aphanamixis polystachya (MELIACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	VOUCHER SPECIMEN REPORTED FOR	None	None
2	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITRO	None	ACTIVE
3	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITRO	None	WEAK ACTIVITY

Azadirachta indica (MELIACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	VOUCHER SPECIMEN REPORTED FOR	None	None
2	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITRO	None	ACTIVE
3	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITRO	None	ACTIVE

Cedrela salvadorensis (MELIACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	VOUCHER SPECIMEN REPORTED FOR	None	None
2	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITRO	None	WEAK ACTIVITY
3	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITRO	None	ACTIVE

Cedrela salvadorensis (MELIACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	VOUCHER SPECIMEN REPORTED FOR	None	None
2	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITRO	None	ACTIVE
3	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITRO	None	ACTIVE

Cedrela salvadorensis (MELIACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	VOUCHER SPECIMEN REPORTED FOR	None	None
2	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITRO	None	ACTIVE
3	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITRO	None	WEAK ACTIVITY

Cedrela salvadorensis (MELIACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	VOUCHER SPECIMEN REPORTED FOR	None	None
2	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITRO	None	ACTIVE
3	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITRO	None	ACTIVE

Cedrela odorata (MELIACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	VOUCHER SPECIMEN REPORTED FOR	None	None
2	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	GEDUNIN	ACTIVE
3	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	GEDUNIN	ACTIVE
4	Not specified	ISOLATION AND IDENTIFICATION OFQUANTITATIVE DATA	GEDUNIN	None
5	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	GEDUNIN	ACTIVE
6	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	GEDUNIN	ACTIVE
7	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	GEDUNIN	ACTIVE

Cedrela odorata (MELIACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	VOUCHER SPECIMEN REPORTED FOR	None	None
2	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITRO	None	ACTIVE
3	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITRO	None	ACTIVE
4	Not specified	ISOLATION AND IDENTIFICATION OFQUANTITATIVE DATA	GEDUNIN	None

Cedrela odorata (MELIACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	VOUCHER SPECIMEN REPORTED FOR	None	None
2	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITRO	None	ACTIVE
3	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITRO	None	ACTIVE
4	Not specified	ISOLATION AND IDENTIFICATION OFQUANTITATIVE DATA	GEDUNIN	None

Chukrasia tabularis (MELIACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	VOUCHER SPECIMEN REPORTED FOR	None	None
2	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITRO	None	ACTIVE
3	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITRO	None	ACTIVE

Dysoxylum fraseranum (MELIACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	VOUCHER SPECIMEN REPORTED FOR	None	None
2	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITRO	None	ACTIVE
3	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITRO	None	WEAK ACTIVITY

Dysoxylum fraseranum (MELIACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	VOUCHER SPECIMEN REPORTED FOR	None	None
2	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITRO	None	ACTIVE
3	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITRO	None	ACTIVE

Guarea glabra (MELIACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	VOUCHER SPECIMEN REPORTED FOR	None	None
2	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITRO	None	ACTIVE
3	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITRO	None	WEAK ACTIVITY

Guarea pyriformis (MELIACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	VOUCHER SPECIMEN REPORTED FOR	None	None
2	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITRO	None	ACTIVE
3	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITRO	None	ACTIVE

Trichilia glabra (MELIACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	VOUCHER SPECIMEN REPORTED FOR	None	None
2	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITRO	None	ACTIVE
3	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITRO	None	ACTIVE

Trichilia hirta (MELIACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	VOUCHER SPECIMEN REPORTED FOR	None	None
2	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITRO	None	ACTIVE
3	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITRO	None	WEAK ACTIVITY

Trichilia trifolia (MELIACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	VOUCHER SPECIMEN REPORTED FOR	None	None
2	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITRO	None	ACTIVE
3	ANTIMALARIAL ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITRO	None	ACTIVE

Citation 135437

Citation Details

Summary

Organisms and Their Experiments (18)

Unknown organism

Aphanamixis polystachya (MELIACEAE)

Azadirachta indica (MELIACEAE)

Cedrela salvadorensis (MELIACEAE)

Cedrela salvadorensis (MELIACEAE)

Cedrela salvadorensis (MELIACEAE)

Cedrela salvadorensis (MELIACEAE)

Cedrela odorata (MELIACEAE)

Cedrela odorata (MELIACEAE)

Cedrela odorata (MELIACEAE)

Chukrasia tabularis (MELIACEAE)

Dysoxylum fraseranum (MELIACEAE)

Dysoxylum fraseranum (MELIACEAE)

Guarea glabra (MELIACEAE)

Guarea pyriformis (MELIACEAE)

Trichilia glabra (MELIACEAE)

Trichilia hirta (MELIACEAE)

Trichilia trifolia (MELIACEAE)

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