Citation 1457

USIA,T: WATABE,T: KADOTA,S: TEZUKA,Y:. (2005). POTENT CYP3A4 INHIBITORY CONSTITUENTS OF PIPER CUBEBA.. 68(1)

Citation Details

Title	POTENT CYP3A4 INHIBITORY CONSTITUENTS OF PIPER CUBEBA.
Authors	USIA,T: WATABE,T: KADOTA,S: TEZUKA,Y:
Year	2005
Volume	68
Issue	1

Summary

Year: 2005

Journal: Unknown

Organisms and Their Experiments (2)

Piper cubeba (PIPERACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	MASS-SPECTRAL FRAGMENTATION REPORTEDPMR SPECTRUM REPORTEDCMR SPECTRUM REPORTEDINFRARED SPECTRUM REPORTED FORQUANTITATIVE DATAISOLATION OF A COMPOUND WITH NOVEL STRUCTURECD SPECTRUM REPORTED FOR	CUBEBINONE,4-HYDROXY: 8(R)-8'(R):	None
2	CYTOCHROME P450 INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CUBEBINONE,4-HYDROXY: 8(R)-8'(R):	INACTIVE
3	CYTOCHROME P450 INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CUBEBINONE,4-HYDROXY: 8(R)-8'(R):	ACTIVE
4	Not specified	MASS-SPECTRAL FRAGMENTATION REPORTEDPMR SPECTRUM REPORTEDCMR SPECTRUM REPORTEDINFRARED SPECTRUM REPORTED FORQUANTITATIVE DATAISOLATION OF A COMPOUND WITH NOVEL STRUCTURECD SPECTRUM REPORTED FOR	CLUSIN,5-METHOXY: 8(R)-8'(R)-9'(S):	None
5	CYTOCHROME P450 INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CLUSIN,5-METHOXY: 8(R)-8'(R)-9'(S):	INACTIVE
6	CYTOCHROME P450 INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CLUSIN,5-METHOXY: 8(R)-8'(R)-9'(S):	ACTIVE
7	Not specified	MASS-SPECTRAL FRAGMENTATION REPORTEDPMR SPECTRUM REPORTEDCMR SPECTRUM REPORTEDINFRARED SPECTRUM REPORTED FORQUANTITATIVE DATAISOLATION OF A COMPOUND WITH NOVEL STRUCTURE	GUAIA-1(10)-3-7(11)-TRIEN-12-8-OLIDE,2-OXO: 5-ALPHA-8-ALPHA:	None
8	CYTOCHROME P450 INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	GUAIA-1(10)-3-7(11)-TRIEN-12-8-OLIDE,2-OXO: 5-ALPHA-8-ALPHA:	INACTIVE
9	CYTOCHROME P450 INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	GUAIA-1(10)-3-7(11)-TRIEN-12-8-OLIDE,2-OXO: 5-ALPHA-8-ALPHA:	ACTIVE
10	Not specified	MASS-SPECTRAL FRAGMENTATION REPORTEDPMR SPECTRUM REPORTEDCMR SPECTRUM REPORTEDINFRARED SPECTRUM REPORTED FORQUANTITATIVE DATAISOLATION OF A COMPOUND WITH NOVEL STRUCTURE	GUAIA-3-7(11)-DIEN-12-8-OLIDE,1-ALPHA-10-ALPHA-EPOXY-2-BETA-HYDROXY: 5-ALPHA-8-ALPHA:	None
11	CYTOCHROME P450 INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	GUAIA-3-7(11)-DIEN-12-8-OLIDE,1-ALPHA-10-ALPHA-EPOXY-2-BETA-HYDROXY: 5-ALPHA-8-ALPHA:	INACTIVE
12	CYTOCHROME P450 INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	GUAIA-3-7(11)-DIEN-12-8-OLIDE,1-ALPHA-10-ALPHA-EPOXY-2-BETA-HYDROXY: 5-ALPHA-8-ALPHA:	WEAK ACTIVITY
13	Not specified	ISOLATION AND IDENTIFICATION OFQUANTITATIVE DATA	ASARONE,ALPHA:	None
14	CYTOCHROME P450 INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	ASARONE,ALPHA:	INACTIVE
15	CYTOCHROME P450 INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	ASARONE,ALPHA:	WEAK ACTIVITY
16	Not specified	ISOLATION AND IDENTIFICATION OFQUANTITATIVE DATA	CUBEBIN,ALPHA-METHYL:	None
17	CYTOCHROME P450 INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CUBEBIN,ALPHA-METHYL:	INACTIVE
18	CYTOCHROME P450 INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CUBEBIN,ALPHA-METHYL:	ACTIVE
19	Not specified	ISOLATION AND IDENTIFICATION OFQUANTITATIVE DATA	MANGOSALIN	None
20	CYTOCHROME P450 INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	MANGOSALIN	INACTIVE
21	CYTOCHROME P450 INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	MANGOSALIN	WEAK ACTIVITY
22	Not specified	ISOLATION AND IDENTIFICATION OFQUANTITATIVE DATA	HINOKININ,(-):	None
23	CYTOCHROME P450 INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	HINOKININ,(-):	WEAK ACTIVITY
24	CYTOCHROME P450 INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	HINOKININ,(-):	ACTIVE
25	Not specified	ISOLATION AND IDENTIFICATION OFQUANTITATIVE DATA	CUBEBIN,(-):	None
26	CYTOCHROME P450 INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CUBEBIN,(-):	WEAK ACTIVITY
27	CYTOCHROME P450 INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CUBEBIN,(-):	ACTIVE
28	Not specified	ISOLATION AND IDENTIFICATION OFQUANTITATIVE DATA	CLUSIN,(-):	None
29	CYTOCHROME P450 INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CLUSIN,(-):	INACTIVE
30	CYTOCHROME P450 INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CLUSIN,(-):	ACTIVE
31	Not specified	ISOLATION AND IDENTIFICATION OFQUANTITATIVE DATA	CUBEBININOLIDE,(-):	None
32	CYTOCHROME P450 INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CUBEBININOLIDE,(-):	INACTIVE
33	CYTOCHROME P450 INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CUBEBININOLIDE,(-):	WEAK ACTIVITY
34	Not specified	ISOLATION AND IDENTIFICATION OFQUANTITATIVE DATA	CUBEBIN,DIHYDRO: (-):	None
35	CYTOCHROME P450 INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CUBEBIN,DIHYDRO: (-):	WEAK ACTIVITY
36	CYTOCHROME P450 INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CUBEBIN,DIHYDRO: (-):	ACTIVE
37	Not specified	ISOLATION AND IDENTIFICATION OFQUANTITATIVE DATA	YATEIN,(-):	None
38	CYTOCHROME P450 INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	YATEIN,(-):	WEAK ACTIVITY
39	CYTOCHROME P450 INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	YATEIN,(-):	ACTIVE
40	Not specified	ISOLATION AND IDENTIFICATION OFQUANTITATIVE DATA	PHENYLACETONE,2-4-5-TRIMETHOXY:	None
41	CYTOCHROME P450 INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PHENYLACETONE,2-4-5-TRIMETHOXY:	INACTIVE
42	CYTOCHROME P450 INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PHENYLACETONE,2-4-5-TRIMETHOXY:	WEAK ACTIVITY
43	Not specified	ISOLATION AND IDENTIFICATION OFQUANTITATIVE DATA	CLUSIN,ETHOXY:	None
44	CYTOCHROME P450 INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CLUSIN,ETHOXY:	WEAK ACTIVITY
45	CYTOCHROME P450 INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CLUSIN,ETHOXY:	ACTIVE
46	Not specified	ISOLATION AND IDENTIFICATION OFQUANTITATIVE DATA	CUBEBININ,(-):	None
47	CYTOCHROME P450 INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CUBEBININ,(-):	INACTIVE
48	CYTOCHROME P450 INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CUBEBININ,(-):	WEAK ACTIVITY
49	Not specified	ISOLATION AND IDENTIFICATION OFQUANTITATIVE DATA	CLUSIN,DIHYDRO:	None
50	CYTOCHROME P450 INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CLUSIN,DIHYDRO:	INACTIVE
51	CYTOCHROME P450 INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CLUSIN,DIHYDRO:	ACTIVE
52	Not specified	ISOLATION AND IDENTIFICATION OFQUANTITATIVE DATA	PROPANE-1-2-DIONE,1-(2-4-5-TRIMETHOXY-PHENYL):	None
53	CYTOCHROME P450 INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PROPANE-1-2-DIONE,1-(2-4-5-TRIMETHOXY-PHENYL):	INACTIVE
54	CYTOCHROME P450 INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PROPANE-1-2-DIONE,1-(2-4-5-TRIMETHOXY-PHENYL):	WEAK ACTIVITY
55	Not specified	ISOLATION AND IDENTIFICATION OFQUANTITATIVE DATA	THUJAPLICATIN TRIMETHYL ETHER,(-):	None
56	CYTOCHROME P450 INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	THUJAPLICATIN TRIMETHYL ETHER,(-):	INACTIVE
57	CYTOCHROME P450 INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	THUJAPLICATIN TRIMETHYL ETHER,(-):	ACTIVE
58	Not specified	ISOLATION AND IDENTIFICATION OFQUANTITATIVE DATA	MEDIORESINOL	None
59	CYTOCHROME P450 INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	MEDIORESINOL	INACTIVE
60	CYTOCHROME P450 INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	MEDIORESINOL	ACTIVE

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	CYTOCHROME P450 INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	QUINIDINE	STRONG ACTIVITY

Citation 1457

Citation Details

Summary

Organisms and Their Experiments (2)

Piper cubeba (PIPERACEAE)

Unknown organism

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