Citation 155501

ALBERTS,AW: CHEN,J: KURON,G: HUNT,V: HUFF,J: HOFFMAN,C: ROTHROCK,J: LOPEZ,M: JOSHUA,H: HARRIS,E: PATCHETT,A: MONAGHAN,R: CURRIE,S: STAPLEY,E: ALBERS-S:. (1980). MEVINOLIN: A HIGHLY POTENT COMPETITIVE INHIBITOR OF HYDROXYMETHYLGLUTARYL-COENZYME A REDUCTASE AND A CHOLESTEROL-LOWERING AGENT.. 77()

Citation Details

Title	MEVINOLIN: A HIGHLY POTENT COMPETITIVE INHIBITOR OF HYDROXYMETHYLGLUTARYL-COENZYME A REDUCTASE AND A CHOLESTEROL-LOWERING AGENT.
Authors	ALBERTS,AW: CHEN,J: KURON,G: HUNT,V: HUFF,J: HOFFMAN,C: ROTHROCK,J: LOPEZ,M: JOSHUA,H: HARRIS,E: PATCHETT,A: MONAGHAN,R: CURRIE,S: STAPLEY,E: ALBERS-S:
Year	1980
Volume	77
Issue

Summary

Year: 1980

Journal: Unknown

Organisms and Their Experiments (2)

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	MEVALONATE-NADP-OXIDOREDUCTASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	MEVINOLINIC ACID	ACTIVE
2	CHOLESTEROL SYNTHESIS INHIBITION	PHARMACOLOGY OF COMPOUND - IN VIVO	MEVINOLINIC ACID	ACTIVE

Aspergillus terreus (HYPHOMYCETES)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	X-RAY DIFFRACTION STUDY OFUV SPECTRUM GIVEN FORMASS-SPECTRAL FRAGMENTATION REPORTEDPMR SPECTRUM REPORTEDCMR SPECTRUM REPORTEDX-RAY CHRYSTALLOGRAPHIC STUDIESINFRARED SPECTRUM REPORTED FORQUANTITATIVE DATAISOLATION OF A COMPOUND WITH NOVEL STRUCTUREYIELD IS MORE THAN 100 MGM	MEVINOLIN	None
2	MEVALONATE-NADP-OXIDOREDUCTASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	MEVINOLIN	ACTIVE
3	HYPERCHOLESTEROLEMIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVO	MEVINOLIN	ACTIVE
4	Not specified	ISOLATION OF A COMPOUND WITH NOVEL STRUCTURE	MEVINOLINIC ACIDMEVINIC ACID	None