GENOTOXICITY OF A VARIETY OF PYRROLIZIDINE ALKALOIDS IN THE HEPATOCYTE PRIMARY CULTURE-DNA REPAIR TEST USING RAT, MOUSE, AND HAMSTER HEPATOCYTES.

Title	GENOTOXICITY OF A VARIETY OF PYRROLIZIDINE ALKALOIDS IN THE HEPATOCYTE PRIMARY CULTURE-DNA REPAIR TEST USING RAT, MOUSE, AND HAMSTER HEPATOCYTES.
Authors	MORI,H: SUGIE,S: YOSHIMI,N: ASADA,Y: FURUYA,T: WILLIAMS,GM:
Year	1985
Volume	45
Issue

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	COMPLETE SYNTHESIS REPORTED	CLIVORINE,DIHYDRO:	None
2	DNA REPAIR INDUCTION	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	CLIVORINE,DIHYDRO:	ACTIVE
3	MUTAGENIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	CLIVORINE,DIHYDRO:	EQUIVOCAL
4	GENOTOXICITY ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	CLIVORINE,DIHYDRO:	EQUIVOCAL

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	COMPLETE SYNTHESIS REPORTED	SENECIPHYLLINE,EPOXY:	None
2	DNA REPAIR INDUCTION	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	SENECIPHYLLINE,EPOXY:	ACTIVE
3	MUTAGENIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	SENECIPHYLLINE,EPOXY:	EQUIVOCAL
4	GENOTOXICITY ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	SENECIPHYLLINE,EPOXY:	EQUIVOCAL

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	COMPLETE SYNTHESIS REPORTED	RETRONECINE	None
2	DNA REPAIR INDUCTION	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	RETRONECINE	INACTIVE
3	MUTAGENIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	RETRONECINE	INACTIVE
4	GENOTOXICITY ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	RETRONECINE	EQUIVOCAL
5	DNA REPAIR INDUCTION	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	RETRONECINE	INACTIVE
6	DNA REPAIR INDUCTION	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	RETRONECINE	INACTIVE

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	DNA REPAIR INDUCTION	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	MONOCROTALINE	ACTIVE
2	MUTAGENIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	MONOCROTALINE	ACTIVE
3	GENOTOXICITY ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	MONOCROTALINE	ACTIVE
4	DNA REPAIR INDUCTION	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	MONOCROTALINE	ACTIVE
5	DNA REPAIR INDUCTION	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	MONOCROTALINE	ACTIVE

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	DNA REPAIR INDUCTION	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	PETASITENINE	ACTIVE
2	MUTAGENIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	PETASITENINE	ACTIVE
3	GENOTOXICITY ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	PETASITENINE	ACTIVE

Ligularia japonica (ASTERACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	ISOLATION AND IDENTIFICATION OF	SENECIONINE	None
2	DNA REPAIR INDUCTION	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	SENECIONINE	ACTIVE
3	MUTAGENIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	SENECIONINE	ACTIVE
4	GENOTOXICITY ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	SENECIONINE	EQUIVOCAL
5	Not specified	ISOLATION AND IDENTIFICATION OF	FUKINOTOXIN,ACETYL:	None
6	DNA REPAIR INDUCTION	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	FUKINOTOXIN,ACETYL:	ACTIVE
7	MUTAGENIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	FUKINOTOXIN,ACETYL:	EQUIVOCAL
8	GENOTOXICITY ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	FUKINOTOXIN,ACETYL:	EQUIVOCAL

Senecio cannabifolius (ASTERACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	ISOLATION AND IDENTIFICATION OF	SENECIPHYLLINE	None
2	DNA REPAIR INDUCTION	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	SENECIPHYLLINE	ACTIVE
3	MUTAGENIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	SENECIPHYLLINE	INACTIVE
4	GENOTOXICITY ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	SENECIPHYLLINE	EQUIVOCAL
5	DNA REPAIR INDUCTION	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	SENECIPHYLLINE	ACTIVE
6	DNA REPAIR INDUCTION	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	SENECIPHYLLINE	ACTIVE
7	Not specified	ISOLATION AND IDENTIFICATION OF	SENECICANNABINE	None
8	DNA REPAIR INDUCTION	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	SENECICANNABINE	ACTIVE
9	MUTAGENIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	SENECICANNABINE	EQUIVOCAL
10	GENOTOXICITY ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	SENECICANNABINE	EQUIVOCAL

Crassocephalum crepidioides (ASTERACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	ISOLATION AND IDENTIFICATION OF	JACOBINE	None
2	DNA REPAIR INDUCTION	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	JACOBINE	ACTIVE
3	MUTAGENIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	JACOBINE	EQUIVOCAL
4	GENOTOXICITY ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	JACOBINE	EQUIVOCAL

Ligularia dentata (ASTERACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	ISOLATION AND IDENTIFICATION OF	LIGULARININE	None
2	DNA REPAIR INDUCTION	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	LIGULARININE	INACTIVE
3	MUTAGENIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	LIGULARININE	EQUIVOCAL
4	GENOTOXICITY ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	LIGULARININE	EQUIVOCAL
5	Not specified	ISOLATION AND IDENTIFICATION OF	LIGULARIDINE	None
6	DNA REPAIR INDUCTION	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	LIGULARIDINE	ACTIVE
7	MUTAGENIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	LIGULARIDINE	ACTIVE
8	GENOTOXICITY ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	LIGULARIDINE	EQUIVOCAL
9	Not specified	ISOLATION AND IDENTIFICATION OF	LIGULARIDINE,NEO:	None
10	DNA REPAIR INDUCTION	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	LIGULARIDINE,NEO:	ACTIVE
11	MUTAGENIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	LIGULARIDINE,NEO:	EQUIVOCAL
12	GENOTOXICITY ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	LIGULARIDINE,NEO:	EQUIVOCAL
13	Not specified	ISOLATION AND IDENTIFICATION OF	LIGULARIZINE	None
14	DNA REPAIR INDUCTION	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	LIGULARIZINE	ACTIVE
15	MUTAGENIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	LIGULARIZINE	EQUIVOCAL
16	GENOTOXICITY ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	LIGULARIZINE	EQUIVOCAL
17	Not specified	ISOLATION AND IDENTIFICATION OF	CLIVORINE	None
18	DNA REPAIR INDUCTION	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	CLIVORINE	ACTIVE
19	MUTAGENIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	CLIVORINE	ACTIVE
20	GENOTOXICITY ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	CLIVORINE	EQUIVOCAL
21	DNA REPAIR INDUCTION	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	CLIVORINE	ACTIVE
22	DNA REPAIR INDUCTION	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	CLIVORINE	INACTIVE

Senecio pierotii (ASTERACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	ISOLATION AND IDENTIFICATION OF	SENKIRKINE	None
2	DNA REPAIR INDUCTION	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	SENKIRKINE	ACTIVE
3	MUTAGENIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	SENKIRKINE	ACTIVE
4	GENOTOXICITY ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	SENKIRKINE	ACTIVE
5	DNA REPAIR INDUCTION	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	SENKIRKINE	ACTIVE
6	DNA REPAIR INDUCTION	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	SENKIRKINE	ACTIVE

Syneilesis palmata (ASTERACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	ISOLATION AND IDENTIFICATION OF	SYNEILESINE	None
2	DNA REPAIR INDUCTION	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	SYNEILESINE	ACTIVE
3	MUTAGENIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	SYNEILESINE	EQUIVOCAL
4	GENOTOXICITY ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROCARCINOGENIC DATA (MARKER CODE)	SYNEILESINE	EQUIVOCAL

Citation 177993

Citation Details

Summary

Organisms and Their Experiments (11)

Unknown organism

Unknown organism

Unknown organism

Unknown organism

Unknown organism

Ligularia japonica (ASTERACEAE)

Senecio cannabifolius (ASTERACEAE)

Crassocephalum crepidioides (ASTERACEAE)

Ligularia dentata (ASTERACEAE)

Senecio pierotii (ASTERACEAE)

Syneilesis palmata (ASTERACEAE)

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