Citation 179491

BROSSI,A: SHARMA,PN: ATWELL,L: JACOBSON,AE: IORIO,MA: MOLINARI,M: CHIGNELL,CF:. (1983). BIOLOGICAL EFFECTS OF MODIFIED COLCHICINES. 2. EVALUATION OF CATECHOLIC COLCHICINES, COLCHIFOLINES, COLCHICIDE, AND NOVEL N-ACYL AND N-AROYLDEACETYLCOLCHICINES.. 26(10)

Citation Details

Title	BIOLOGICAL EFFECTS OF MODIFIED COLCHICINES. 2. EVALUATION OF CATECHOLIC COLCHICINES, COLCHIFOLINES, COLCHICIDE, AND NOVEL N-ACYL AND N-AROYLDEACETYLCOLCHICINES.
Authors	BROSSI,A: SHARMA,PN: ATWELL,L: JACOBSON,AE: IORIO,MA: MOLINARI,M: CHIGNELL,CF:
Year	1983
Volume	26
Issue	10

Summary

Year: 1983

Journal: Unknown

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVOANTICANCER AND/OR CYTOTOXICITY MARKER CODE	COLCHICINE	ACTIVE
2	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	COLCHICINE	INACTIVE

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVOANTICANCER AND/OR CYTOTOXICITY MARKER CODE	CORNIGERINE	ACTIVE
2	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CORNIGERINE	ACTIVE

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVOANTICANCER AND/OR CYTOTOXICITY MARKER CODE	COLCHICINE,1-2-DEMETHYL-1-2-METHYLENEDIOXY:	INACTIVE
2	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	COLCHICINE,1-2-DEMETHYL-1-2-METHYLENEDIOXY:	ACTIVE

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVOANTICANCER AND/OR CYTOTOXICITY MARKER CODE	COLCHICINE,1-2-DIDEMETHYL:	INACTIVE
2	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	COLCHICINE,1-2-DIDEMETHYL:	STRONG ACTIVITY

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVOANTICANCER AND/OR CYTOTOXICITY MARKER CODE	COLCHICINE,2-3-DIDEMETHYL:	ACTIVE
2	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	COLCHICINE,2-3-DIDEMETHYL:	ACTIVE

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	COMPLETE SYNTHESIS REPORTED	COLCHICINE,2-DEMETHYL: 2-O-(N-PHENYL-TETRAZOLYL):	None
2	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	COLCHICINE,2-DEMETHYL: 2-O-(N-PHENYL-TETRAZOLYL):	ACTIVE

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	COMPLETE SYNTHESIS REPORTED	COLCHICINE,3-DEMETHYL: 3-O-(N-PHENYL-TETRAZOLYL):	None
2	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	COLCHICINE,3-DEMETHYL: 3-O-(N-PHENYL-TETRAZOLYL):	ACTIVE

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVOANTICANCER AND/OR CYTOTOXICITY MARKER CODE	COLCHIFOLINE	ACTIVE
2	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	COLCHIFOLINE	ACTIVE

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	COMPLETE SYNTHESIS REPORTED	COLCHIFOLINE,N-METHYL:	None
2	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVOANTICANCER AND/OR CYTOTOXICITY MARKER CODE	COLCHIFOLINE,N-METHYL:	ACTIVE
3	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	COLCHIFOLINE,N-METHYL:	ACTIVE

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVOANTICANCER AND/OR CYTOTOXICITY MARKER CODE	COLCHIFOLINE,O-ETHYL:	ACTIVE
2	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	COLCHIFOLINE,O-ETHYL:	WEAK ACTIVITY

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVOANTICANCER AND/OR CYTOTOXICITY MARKER CODE	COLCHICINE,DEACETYL: N-BENZOYL:	ACTIVE
2	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	COLCHICINE,DEACETYL: N-BENZOYL:	INACTIVE

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	COMPLETE SYNTHESIS REPORTED	COLCHICINE,DEACETYL: N-PROPIONYL:	None
2	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	COLCHICINE,DEACETYL: N-PROPIONYL:	INACTIVE

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	COMPLETE SYNTHESIS REPORTED	COLCHICINE,ISO: DEACETYL: N-PROPIONYL:	None
2	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	COLCHICINE,ISO: DEACETYL: N-PROPIONYL:	ACTIVE

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	COMPLETE SYNTHESIS REPORTED	COLCHICINE,DEACETYL: N-BUTYRYL:	None
2	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVOANTICANCER AND/OR CYTOTOXICITY MARKER CODE	COLCHICINE,DEACETYL: N-BUTYRYL:	ACTIVE
3	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	COLCHICINE,DEACETYL: N-BUTYRYL:	INACTIVE

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	COMPLETE SYNTHESIS REPORTED	COLCHICINE,DEACETYL: N-PIVALOYL:	None
2	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	COLCHICINE,DEACETYL: N-PIVALOYL:	ACTIVE

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	COMPLETE SYNTHESIS REPORTED	COLCHICINE,DEACETYL: N-(3-4-5-TRIMETHOXY-BENZOYL):	None
2	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVOANTICANCER AND/OR CYTOTOXICITY MARKER CODE	COLCHICINE,DEACETYL: N-(3-4-5-TRIMETHOXY-BENZOYL):	ACTIVE
3	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	COLCHICINE,DEACETYL: N-(3-4-5-TRIMETHOXY-BENZOYL):	ACTIVE

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	COMPLETE SYNTHESIS REPORTED	COLCHICINE,DEACETYL: N-CARBETHOXY:	None
2	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVOANTICANCER AND/OR CYTOTOXICITY MARKER CODE	COLCHICINE,DEACETYL: N-CARBETHOXY:	ACTIVE
3	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	COLCHICINE,DEACETYL: N-CARBETHOXY:	ACTIVE

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	COMPLETE SYNTHESIS REPORTED	COLCHICINE,DEACETYL:	None
2	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVOANTICANCER AND/OR CYTOTOXICITY MARKER CODE	COLCHICINE,DEACETYL:	ACTIVE
3	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	COLCHICINE,DEACETYL:	INACTIVE

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVOANTICANCER AND/OR CYTOTOXICITY MARKER CODE	COLCHICINE,DEACETYL: 2-DEMETHYL-N-(TRIFLUORO-ACETYL):	ACTIVE
2	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	COLCHICINE,DEACETYL: 2-DEMETHYL-N-(TRIFLUORO-ACETYL):	INACTIVE

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	COMPLETE SYNTHESIS REPORTED	COLCHICINE,DEACETYL: RETINOYL:	None
2	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	COLCHICINE,DEACETYL: RETINOYL:	ACTIVE

Citation 179491

Citation Details

Summary

Organisms and Their Experiments (25)

Query 1

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	COMPLETE SYNTHESIS REPORTED	COLCHICINE,DEACETYL: N-(ACETOXY-SINAPINOYL):	None
2	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	COLCHICINE,DEACETYL: N-(ACETOXY-SINAPINOYL):	ACTIVE

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	COMPLETE SYNTHESIS REPORTED	COLCHICINE,DEACETYL: N-SINAPINOYL:	None
2	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	COLCHICINE,DEACETYL: N-SINAPINOYL:	ACTIVE

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	COMPLETE SYNTHESIS REPORTED	COLCHICIDE	None
2	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVOANTICANCER AND/OR CYTOTOXICITY MARKER CODE	COLCHICIDE	ACTIVE
3	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VIVO	COLCHICIDE	INACTIVE