Citation 32925

LIN,CM: SINGH,SB: CHU,PS: DEMPCY,RO: SCHMIDT,JM: PETTIT,GR: HAMEL,E:. (1988). INTERACTIONS OF TUBULIN WITH POTENT NATURAL AND SYNTHETIC ANALOGS OF THE ANTIMITOTIC AGENT COMBRETASTATIN: A STRUCTURE ACTIVITY STUDY.. 34()

Citation Details

Title	INTERACTIONS OF TUBULIN WITH POTENT NATURAL AND SYNTHETIC ANALOGS OF THE ANTIMITOTIC AGENT COMBRETASTATIN: A STRUCTURE ACTIVITY STUDY.
Authors	LIN,CM: SINGH,SB: CHU,PS: DEMPCY,RO: SCHMIDT,JM: PETTIT,GR: HAMEL,E:
Year	1988
Volume	34
Issue

Summary

Year: 1988

Journal: Unknown

Organisms and Their Experiments (17)

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODEANTICANCER AND/OR CYTOTOXICITY MARKER CODE	COMBRETASTATIN A-4	STRONG ACTIVITY
2	ANTIMITOTIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODE	COMBRETASTATIN A-4	ACTIVE
3	TUBULIN POLYMERIZATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODE	COMBRETASTATIN A-4	ACTIVE

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODEANTICANCER AND/OR CYTOTOXICITY MARKER CODE	COMBRETASTATIN A-1	ACTIVE
2	ANTIMITOTIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODE	COMBRETASTATIN A-1	ACTIVE
3	TUBULIN POLYMERIZATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODE	COMBRETASTATIN A-1	ACTIVE

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODEANTICANCER AND/OR CYTOTOXICITY MARKER CODE	COMBRETASTATIN B-1	ACTIVE
2	ANTIMITOTIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODE	COMBRETASTATIN B-1	ACTIVE
3	TUBULIN POLYMERIZATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODE	COMBRETASTATIN B-1	ACTIVE

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODEANTICANCER AND/OR CYTOTOXICITY MARKER CODE	COMBRETASTATIN A-3	STRONG ACTIVITY
2	ANTIMITOTIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODE	COMBRETASTATIN A-3	ACTIVE
3	TUBULIN POLYMERIZATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODE	COMBRETASTATIN A-3	ACTIVE

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODEANTICANCER AND/OR CYTOTOXICITY MARKER CODE	COMBRETASTATIN B-2	ACTIVE
2	ANTIMITOTIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODE	COMBRETASTATIN B-2	ACTIVE
3	TUBULIN POLYMERIZATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODE	COMBRETASTATIN B-2	ACTIVE

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODEANTICANCER AND/OR CYTOTOXICITY MARKER CODE	COMBRETASTATIN A-5	ACTIVE
2	ANTIMITOTIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODE	COMBRETASTATIN A-5	ACTIVE
3	TUBULIN POLYMERIZATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODE	COMBRETASTATIN A-5	ACTIVE

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODEANTICANCER AND/OR CYTOTOXICITY MARKER CODE	COMBRETASTATIN	STRONG ACTIVITY
2	ANTIMITOTIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODE	COMBRETASTATIN	ACTIVE
3	TUBULIN POLYMERIZATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODE	COMBRETASTATIN	ACTIVE

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODEANTICANCER AND/OR CYTOTOXICITY MARKER CODE	ETHANE,1-(3'-5'-DIMETHOXY-PHENYL)-2-(3''-HYDROXY-4''-METHOXY-PHENYL):	ACTIVE
2	ANTIMITOTIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODE	ETHANE,1-(3'-5'-DIMETHOXY-PHENYL)-2-(3''-HYDROXY-4''-METHOXY-PHENYL):	ACTIVE
3	TUBULIN POLYMERIZATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODE	ETHANE,1-(3'-5'-DIMETHOXY-PHENYL)-2-(3''-HYDROXY-4''-METHOXY-PHENYL):	ACTIVE

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODEANTICANCER AND/OR CYTOTOXICITY MARKER CODE	COMBRETASTATIN B-4	ACTIVE
2	ANTIMITOTIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODE	COMBRETASTATIN B-4	ACTIVE
3	TUBULIN POLYMERIZATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODE	COMBRETASTATIN B-4	ACTIVE

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODEANTICANCER AND/OR CYTOTOXICITY MARKER CODE	COMBRETASTATIN B-3	ACTIVE
2	ANTIMITOTIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODE	COMBRETASTATIN B-3	ACTIVE
3	TUBULIN POLYMERIZATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODE	COMBRETASTATIN B-3	INACTIVE

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODEANTICANCER AND/OR CYTOTOXICITY MARKER CODE	ETHANE,1-(3'-5'-DIMETHOXY-PHENYL)-2-(4''-HYDROXY-PHENYL):	ACTIVE
2	ANTIMITOTIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODE	ETHANE,1-(3'-5'-DIMETHOXY-PHENYL)-2-(4''-HYDROXY-PHENYL):	ACTIVE
3	TUBULIN POLYMERIZATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODE	ETHANE,1-(3'-5'-DIMETHOXY-PHENYL)-2-(4''-HYDROXY-PHENYL):	INACTIVE

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODEANTICANCER AND/OR CYTOTOXICITY MARKER CODE	ETHANE,1-(3'-4'-5'-TRIMETHOXY-PHENYL)-2-(4''-HYDROXY-PHENYL):	ACTIVE
2	ANTIMITOTIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODE	ETHANE,1-(3'-4'-5'-TRIMETHOXY-PHENYL)-2-(4''-HYDROXY-PHENYL):	ACTIVE
3	TUBULIN POLYMERIZATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODE	ETHANE,1-(3'-4'-5'-TRIMETHOXY-PHENYL)-2-(4''-HYDROXY-PHENYL):	INACTIVE

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODEANTICANCER AND/OR CYTOTOXICITY MARKER CODE	COMBRETASTATIN A-2	STRONG ACTIVITY
2	ANTIMITOTIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODE	COMBRETASTATIN A-2	ACTIVE
3	TUBULIN POLYMERIZATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODE	COMBRETASTATIN A-2	ACTIVE

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODEANTICANCER AND/OR CYTOTOXICITY MARKER CODE	PHENANTHRENE,7-HYDROXY-2-3-4-6-TETRAMETHOXY:	ACTIVE
2	ANTIMITOTIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODE	PHENANTHRENE,7-HYDROXY-2-3-4-6-TETRAMETHOXY:	ACTIVE
3	TUBULIN POLYMERIZATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODE	PHENANTHRENE,7-HYDROXY-2-3-4-6-TETRAMETHOXY:	WEAK ACTIVITY

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODEANTICANCER AND/OR CYTOTOXICITY MARKER CODE	PHENANTHRENE,9-10-DIHYDRO: 7-HYDROXY-2-3-4-6-TETRAMETHOXY:	ACTIVE
2	ANTIMITOTIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODE	PHENANTHRENE,9-10-DIHYDRO: 7-HYDROXY-2-3-4-6-TETRAMETHOXY:	ACTIVE
3	TUBULIN POLYMERIZATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODE	PHENANTHRENE,9-10-DIHYDRO: 7-HYDROXY-2-3-4-6-TETRAMETHOXY:	INACTIVE

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODEANTICANCER AND/OR CYTOTOXICITY MARKER CODE	PHENANTHRENE,9-10-DIHYDRO: 6-7-DIHYDROXY-2-3-4-TRIMETHOXY:	ACTIVE
2	TUBULIN POLYMERIZATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODE	PHENANTHRENE,9-10-DIHYDRO: 6-7-DIHYDROXY-2-3-4-TRIMETHOXY:	INACTIVE

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODEANTICANCER AND/OR CYTOTOXICITY MARKER CODE	PHENANTHRENE,9-10-DIHYDRO: 2-7-DIHYDROXY-3-4-6-TRIMETHOXY:	ACTIVE
2	TUBULIN POLYMERIZATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODE	PHENANTHRENE,9-10-DIHYDRO: 2-7-DIHYDROXY-3-4-6-TRIMETHOXY:	INACTIVE

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