DNA AS AN AFFINITY PROBE USEFUL IN THE DETECTION AND ISOLATION OF BIOLOGICALLY ACTIVE NATURAL PRODUCTS.

Title	DNA AS AN AFFINITY PROBE USEFUL IN THE DETECTION AND ISOLATION OF BIOLOGICALLY ACTIVE NATURAL PRODUCTS.
Authors	PEZZUTO,JM: CHE,CT: MC PHERSON,DD: ZHU,JP: TOPCU,G: ERDELMEIER,CAJ: CORDELL,GA:
Year	1991
Volume	54
Issue	6

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	DNA BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	MONTACEPHALIN	ACTIVE
2	RNA BINDING	PHARMACOLOGY OF COMPOUND - IN VITRO	MONTACEPHALIN	INACTIVE

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	DNA BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	ELLIPTICINE	ACTIVE
2	RNA BINDING	PHARMACOLOGY OF COMPOUND - IN VITRO	ELLIPTICINE	ACTIVE

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	DNA BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	ADRIAMYCIN	ACTIVE
2	RNA BINDING	PHARMACOLOGY OF COMPOUND - IN VITRO	ADRIAMYCIN	ACTIVE

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	DNA BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	RUBICIN	ACTIVE

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	DNA BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	COLCHICINE	WEAK ACTIVITY
2	RNA BINDING	PHARMACOLOGY OF COMPOUND - IN VITRO	COLCHICINE	WEAK ACTIVITY

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	DNA BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	BLEOMYCIN	WEAK ACTIVITY
2	RNA BINDING	PHARMACOLOGY OF COMPOUND - IN VITRO	BLEOMYCIN	ACTIVE

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	DNA BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	ACRONYCINE	WEAK ACTIVITY

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	DNA BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	STEVIOL	INACTIVE

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	DNA BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	TOMENCEPHALIN,5-HYDROXY:	ACTIVE
2	RNA BINDING	PHARMACOLOGY OF COMPOUND - IN VITRO	TOMENCEPHALIN,5-HYDROXY:	WEAK ACTIVITY
3	DNA BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	JACARANONEPARTHENOLIDE	ACTIVE
4	RNA BINDING	PHARMACOLOGY OF COMPOUND - IN VITRO	JACARANONEPARTHENOLIDE	WEAK ACTIVITY

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	DNA BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	TOMENCEPHALIN	ACTIVE
2	DNA BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	CANTHIN-6-ONE,10-METHOXY:	ACTIVE

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	DNA BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	KAUR-16-EN-19-OIC ACID,ENT:	INACTIVE
2	DNA BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	KAUR-16-EN-19-OIC ACID,15-CINNAMOYL: ENT:MONOGYNOIC ACID	INACTIVE

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	DNA BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	FAGARONINE	ACTIVE
2	RNA BINDING	PHARMACOLOGY OF COMPOUND - IN VITRO	FAGARONINE	ACTIVE

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	DNA BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	CAMPTOTHECIN	INACTIVE
2	RNA BINDING	PHARMACOLOGY OF COMPOUND - IN VITRO	CAMPTOTHECIN	INACTIVE
3	DNA BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	STREBLOSIDECHAPARRINONE,6-ALPHA-SENECIOYL-OXY:PODOPHYLLOTOXIN	INACTIVE
4	RNA BINDING	PHARMACOLOGY OF COMPOUND - IN VITRO	STREBLOSIDECHAPARRINONE,6-ALPHA-SENECIOYL-OXY:PODOPHYLLOTOXIN	INACTIVE

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	DNA BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	ACTINOMYCIN D	ACTIVE
2	RNA BINDING	PHARMACOLOGY OF COMPOUND - IN VITRO	ACTINOMYCIN D	WEAK ACTIVITY

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	DNA BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	LEUROCRISTINE	ACTIVE
2	RNA BINDING	PHARMACOLOGY OF COMPOUND - IN VITRO	LEUROCRISTINE	ACTIVE
3	DNA BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	VINCALEUKOBLASTINE	ACTIVE
4	RNA BINDING	PHARMACOLOGY OF COMPOUND - IN VITRO	VINCALEUKOBLASTINE	ACTIVE

Albizia amara (FABACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	VOUCHER SPECIMEN REPORTED FOR	None	None
2	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	None	WEAK ACTIVITY
3	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	None	ACTIVE
4	DNA BINDING EFFECT	PHARMACOLOGY OF EXTRACT - IN VITRO	None	ACTIVE

Caraipa fasiculata (CLUSIACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	VOUCHER SPECIMEN REPORTED FOR	None	None
2	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	None	INACTIVE
3	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	None	INACTIVE
4	DNA BINDING EFFECT	PHARMACOLOGY OF EXTRACT - IN VITRO	None	INACTIVE

Cerbera manghas (APOCYNACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	VOUCHER SPECIMEN REPORTED FOR	None	None
2	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	None	INACTIVE
3	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	None	INACTIVE
4	DNA BINDING EFFECT	PHARMACOLOGY OF EXTRACT - IN VITRO	None	INACTIVE

Cunuria spruceana (EUPHORBIACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	VOUCHER SPECIMEN REPORTED FOR	None	None
2	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	None	INACTIVE
3	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	None	ACTIVE
4	DNA BINDING EFFECT	PHARMACOLOGY OF EXTRACT - IN VITRO	None	INACTIVE

Erythrina rubrinervia (FABACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	VOUCHER SPECIMEN REPORTED FOR	None	None
2	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	None	INACTIVE
3	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	None	INACTIVE
4	DNA BINDING EFFECT	PHARMACOLOGY OF EXTRACT - IN VITRO	None	INACTIVE

Euphorbia cotinifolia (EUPHORBIACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	VOUCHER SPECIMEN REPORTED FOR	None	None
2	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	None	INACTIVE
3	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	None	INACTIVE
4	DNA BINDING EFFECT	PHARMACOLOGY OF EXTRACT - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	None	ACTIVE

Funtumia africana (APOCYNACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	VOUCHER SPECIMEN REPORTED FOR	None	None
2	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	None	INACTIVE
3	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	None	INACTIVE
4	DNA BINDING EFFECT	PHARMACOLOGY OF EXTRACT - IN VITRO	None	ACTIVE

Jamesonia imbricata (PTERIDACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	VOUCHER SPECIMEN REPORTED FOR	None	None
2	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	None	WEAK ACTIVITY
3	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	None	INACTIVE
4	DNA BINDING EFFECT	PHARMACOLOGY OF EXTRACT - IN VITRO	None	INACTIVE

Laurelia novae-zelandiae (MONIMIACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	VOUCHER SPECIMEN REPORTED FOR	None	None
2	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	None	INACTIVE
3	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	None	WEAK ACTIVITY
4	DNA BINDING EFFECT	PHARMACOLOGY OF EXTRACT - IN VITRO	None	INACTIVE

Olea europaea (OLEACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	VOUCHER SPECIMEN REPORTED FOR	None	None
2	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	None	INACTIVE
3	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	None	WEAK ACTIVITY
4	DNA BINDING EFFECT	PHARMACOLOGY OF EXTRACT - IN VITRO	None	INACTIVE

Pourouma palmata (URTICACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	VOUCHER SPECIMEN REPORTED FOR	None	None
2	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	None	WEAK ACTIVITY
3	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	None	WEAK ACTIVITY
4	DNA BINDING EFFECT	PHARMACOLOGY OF EXTRACT - IN VITRO	None	INACTIVE

Salix humboldtiana (SALICACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	VOUCHER SPECIMEN REPORTED FOR	None	None
2	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	None	INACTIVE
3	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	None	WEAK ACTIVITY
4	DNA BINDING EFFECT	PHARMACOLOGY OF EXTRACT - IN VITRO	None	INACTIVE

Salix humboldtiana (SALICACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	VOUCHER SPECIMEN REPORTED FOR	None	None
2	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	None	ACTIVE
3	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	None	ACTIVE
4	DNA BINDING EFFECT	PHARMACOLOGY OF EXTRACT - IN VITRO	None	ACTIVE

Schefflera bogotensis (ARALIACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	VOUCHER SPECIMEN REPORTED FOR	None	None
2	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	None	INACTIVE
3	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	None	INACTIVE
4	DNA BINDING EFFECT	PHARMACOLOGY OF EXTRACT - IN VITRO	None	INACTIVE

Strophanthus hispidus (APOCYNACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	VOUCHER SPECIMEN REPORTED FOR	None	None
2	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	None	ACTIVE
3	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	None	WEAK ACTIVITY
4	DNA BINDING EFFECT	PHARMACOLOGY OF EXTRACT - IN VITRO	None	INACTIVE

Typha domingensis (TYPHACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	VOUCHER SPECIMEN REPORTED FOR	None	None
2	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	None	INACTIVE
3	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	None	INACTIVE
4	DNA BINDING EFFECT	PHARMACOLOGY OF EXTRACT - IN VITRO	None	ACTIVE

Xylopia aromatica (ANNONACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	VOUCHER SPECIMEN REPORTED FOR	None	None
2	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	None	WEAK ACTIVITY
3	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF EXTRACT - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	None	ACTIVE
4	DNA BINDING EFFECT	PHARMACOLOGY OF EXTRACT - IN VITRO	None	INACTIVE

Citation 39855

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Organisms and Their Experiments (32)

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Albizia amara (FABACEAE)

Caraipa fasiculata (CLUSIACEAE)

Cerbera manghas (APOCYNACEAE)

Cunuria spruceana (EUPHORBIACEAE)

Erythrina rubrinervia (FABACEAE)

Euphorbia cotinifolia (EUPHORBIACEAE)

Funtumia africana (APOCYNACEAE)

Jamesonia imbricata (PTERIDACEAE)

Laurelia novae-zelandiae (MONIMIACEAE)

Olea europaea (OLEACEAE)

Pourouma palmata (URTICACEAE)

Salix humboldtiana (SALICACEAE)

Salix humboldtiana (SALICACEAE)

Schefflera bogotensis (ARALIACEAE)

Strophanthus hispidus (APOCYNACEAE)

Typha domingensis (TYPHACEAE)

Xylopia aromatica (ANNONACEAE)

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