Citation 59768

DELBARRE,A: OBERLIN,R: ROQUES,BP: BORGNA,JL: ROCHEFORT,H: LE PECQ,JB: JACQUEMIN-SABLON,A:. (1985). ELLIPTICINE DERIVATIVES WITH AN AFFINITY TO THE ESTROGEN RECEPTOR, AN APPROACH TO DEVELOP INTERCALATING DRUGS WITH A SPECIFIC EFFECT ON THE HORMONE-DEPENDENT BREAST CANCER.. 28(6)

Citation Details

Title	ELLIPTICINE DERIVATIVES WITH AN AFFINITY TO THE ESTROGEN RECEPTOR, AN APPROACH TO DEVELOP INTERCALATING DRUGS WITH A SPECIFIC EFFECT ON THE HORMONE-DEPENDENT BREAST CANCER.
Authors	DELBARRE,A: OBERLIN,R: ROQUES,BP: BORGNA,JL: ROCHEFORT,H: LE PECQ,JB: JACQUEMIN-SABLON,A:
Year	1985
Volume	28
Issue	6

Summary

Year: 1985

Journal: Unknown

Organisms and Their Experiments (8)

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	DNA BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	ELLIPTICINE	ACTIVE
2	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	ELLIPTICINE	ACTIVE

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	DNA BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	ELLIPTICINE,9-METHOXY-2-METHYL:	ACTIVE

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	COMPLETE SYNTHESIS REPORTED	ELLIPTICINE,2-(3-AZA-5-(3-17-BETA-DIHYDROXY-1-3-5-ESTRATRIEN-17-ALPHA-YL)-4-OXO-PENTAMETHYLENE):	None
2	DNA INTERCALATING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	ELLIPTICINE,2-(3-AZA-5-(3-17-BETA-DIHYDROXY-1-3-5-ESTRATRIEN-17-ALPHA-YL)-4-OXO-PENTAMETHYLENE):	ACTIVE
3	DNA BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	ELLIPTICINE,2-(3-AZA-5-(3-17-BETA-DIHYDROXY-1-3-5-ESTRATRIEN-17-ALPHA-YL)-4-OXO-PENTAMETHYLENE):	ACTIVE
4	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	ELLIPTICINE,2-(3-AZA-5-(3-17-BETA-DIHYDROXY-1-3-5-ESTRATRIEN-17-ALPHA-YL)-4-OXO-PENTAMETHYLENE):	ACTIVE
5	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	ELLIPTICINE,2-(3-AZA-5-(3-17-BETA-DIHYDROXY-1-3-5-ESTRATRIEN-17-ALPHA-YL)-4-OXO-PENTAMETHYLENE):	ACTIVE

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	COMPLETE SYNTHESIS REPORTED	ELLIPTICINE,9-HYDROXY: TRANS-2-(11-(4-(2-CHLORO-1-2-DIPHENYL-ETHENYL)-PHENOXY)-3-9-DIAZA-9-((9-METHOXY-2-ELLIPTICINO)-ACETHYL)-2-OXO-UNDECAMETHYLENE):	None
2	DNA INTERCALATING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	ELLIPTICINE,9-HYDROXY: TRANS-2-(11-(4-(2-CHLORO-1-2-DIPHENYL-ETHENYL)-PHENOXY)-3-9-DIAZA-9-((9-METHOXY-2-ELLIPTICINO)-ACETHYL)-2-OXO-UNDECAMETHYLENE):	ACTIVE
3	DNA BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	ELLIPTICINE,9-HYDROXY: TRANS-2-(11-(4-(2-CHLORO-1-2-DIPHENYL-ETHENYL)-PHENOXY)-3-9-DIAZA-9-((9-METHOXY-2-ELLIPTICINO)-ACETHYL)-2-OXO-UNDECAMETHYLENE):	ACTIVE
4	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	ELLIPTICINE,9-HYDROXY: TRANS-2-(11-(4-(2-CHLORO-1-2-DIPHENYL-ETHENYL)-PHENOXY)-3-9-DIAZA-9-((9-METHOXY-2-ELLIPTICINO)-ACETHYL)-2-OXO-UNDECAMETHYLENE):	ACTIVE

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	COMPLETE SYNTHESIS REPORTED	ELLIPTICINE,9-HYDROXY: TRANS-2-(11-(4-(2-CHLORO-1-2-DIPHENYL-ETHENYL)-PHENOXY)-3-9-DIAZA-9-((9-HYDROXY-2-ELLIPTICINO)-ACETYL)-2-OXO-UNDECAMETHYLENE):	None
2	DNA INTERCALATING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	ELLIPTICINE,9-HYDROXY: TRANS-2-(11-(4-(2-CHLORO-1-2-DIPHENYL-ETHENYL)-PHENOXY)-3-9-DIAZA-9-((9-HYDROXY-2-ELLIPTICINO)-ACETYL)-2-OXO-UNDECAMETHYLENE):	ACTIVE
3	DNA BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	ELLIPTICINE,9-HYDROXY: TRANS-2-(11-(4-(2-CHLORO-1-2-DIPHENYL-ETHENYL)-PHENOXY)-3-9-DIAZA-9-((9-HYDROXY-2-ELLIPTICINO)-ACETYL)-2-OXO-UNDECAMETHYLENE):	ACTIVE

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	COMPLETE SYNTHESIS REPORTED	ELLIPTICINE,9-METHOXY: TRANS-2-(8-AMINO-3-AZA-3-(2-(4-(2-CHLORO-1-2-DIPHENYL-ETHENYL)-PHENOXY)-ETHYL)-2-OXO-OCTAMETHYLENE):	None
2	DNA INTERCALATING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	ELLIPTICINE,9-METHOXY: TRANS-2-(8-AMINO-3-AZA-3-(2-(4-(2-CHLORO-1-2-DIPHENYL-ETHENYL)-PHENOXY)-ETHYL)-2-OXO-OCTAMETHYLENE):	ACTIVE
3	DNA BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	ELLIPTICINE,9-METHOXY: TRANS-2-(8-AMINO-3-AZA-3-(2-(4-(2-CHLORO-1-2-DIPHENYL-ETHENYL)-PHENOXY)-ETHYL)-2-OXO-OCTAMETHYLENE):	ACTIVE
4	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	ELLIPTICINE,9-METHOXY: TRANS-2-(8-AMINO-3-AZA-3-(2-(4-(2-CHLORO-1-2-DIPHENYL-ETHENYL)-PHENOXY)-ETHYL)-2-OXO-OCTAMETHYLENE):	ACTIVE

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	COMPLETE SYNTHESIS REPORTED	ELLIPTICINE,9-METHOXY: TRANS-2-(3-9-DIAZA-11-(4-(2-CHLORO-1-2-DIPHENYL-ETHENYL)-PHENOXY)-2-OXO-UNDECAMETHYLENE):	None
2	DNA INTERCALATING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	ELLIPTICINE,9-METHOXY: TRANS-2-(3-9-DIAZA-11-(4-(2-CHLORO-1-2-DIPHENYL-ETHENYL)-PHENOXY)-2-OXO-UNDECAMETHYLENE):	ACTIVE
3	DNA BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	ELLIPTICINE,9-METHOXY: TRANS-2-(3-9-DIAZA-11-(4-(2-CHLORO-1-2-DIPHENYL-ETHENYL)-PHENOXY)-2-OXO-UNDECAMETHYLENE):	ACTIVE

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	COMPLETE SYNTHESIS REPORTED	ELLIPTICINE,9-HYDROXY: TRANS-2-(3-9-DIAZA-11-(4-(2-CHLORO-1-2-DIPHENYL-ETHENYL)-PHENOXY)-2-OXO-UNDECAMETHYLENE):	None
2	DNA INTERCALATING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	ELLIPTICINE,9-HYDROXY: TRANS-2-(3-9-DIAZA-11-(4-(2-CHLORO-1-2-DIPHENYL-ETHENYL)-PHENOXY)-2-OXO-UNDECAMETHYLENE):	ACTIVE
3	DNA BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	ELLIPTICINE,9-HYDROXY: TRANS-2-(3-9-DIAZA-11-(4-(2-CHLORO-1-2-DIPHENYL-ETHENYL)-PHENOXY)-2-OXO-UNDECAMETHYLENE):	ACTIVE
4	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	ELLIPTICINE,9-HYDROXY: TRANS-2-(3-9-DIAZA-11-(4-(2-CHLORO-1-2-DIPHENYL-ETHENYL)-PHENOXY)-2-OXO-UNDECAMETHYLENE):	ACTIVE

Citation 59768

Citation Details

Summary

Organisms and Their Experiments (8)

Unknown organism

Unknown organism

Unknown organism

Unknown organism

Unknown organism

Unknown organism

Unknown organism

Unknown organism

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