Citation 78948

FU,X: SCHMITZ,FJ: GOVINDAN,M: ABBAS,SA: HANSON,KM: HORTON,PA: CREWS,P: LANEY,M: SCHATZMAN,RC:. (1995). ENZYME INHIBITORS: NEW AND KNOWN POLYBROMINATED PHENOLS AND DIPHENYL ETHERS FROM FOUR INDO-PACIFIC DYSIDEA SPONGES.. 58(9)

Citation Details

Title	ENZYME INHIBITORS: NEW AND KNOWN POLYBROMINATED PHENOLS AND DIPHENYL ETHERS FROM FOUR INDO-PACIFIC DYSIDEA SPONGES.
Authors	FU,X: SCHMITZ,FJ: GOVINDAN,M: ABBAS,SA: HANSON,KM: HORTON,PA: CREWS,P: LANEY,M: SCHATZMAN,RC:
Year	1995
Volume	58
Issue	9

Summary

Year: 1995

Journal: Unknown

Organisms and Their Experiments (4)

Dysidea species (5-t-92) (DYSIDEIDAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	VOUCHER SPECIMEN REPORTED FORMASS-SPECTRAL FRAGMENTATION REPORTEDPMR SPECTRUM REPORTEDINFRARED SPECTRUM REPORTED FORQUANTITATIVE DATAISOLATION OF A COMPOUND WITH NOVEL STRUCTURE	PHENOL,2-3-DIBROMO-5-HYDROXY:	None
2	LIPOXYGENASE,15: INHIBITION	PHARMACOLOGY OF EXTRACT - IN VITRO	None	WEAK ACTIVITY
3	INOSINE MONOPHOSPHATE DEHYDROGENASE INHIBITION	PHARMACOLOGY OF EXTRACT - IN VITRO	None	INACTIVE
4	LIPOXYGENASE,15: INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PHENOL,2-3-DIBROMO-5-HYDROXY:	WEAK ACTIVITY
5	INOSINE MONOPHOSPHATE DEHYDROGENASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PHENOL,2-3-DIBROMO-5-HYDROXY:	INACTIVE
6	Not specified	ISOLATION AND IDENTIFICATION OFMASS-SPECTRAL FRAGMENTATION REPORTEDPMR SPECTRUM REPORTEDINFRARED SPECTRUM REPORTED FORQUANTITATIVE DATA	PHENOL,3-5-DIBROMO-2-HYDROXY:	None
7	Not specified	ISOLATION AND IDENTIFICATION OFQUANTITATIVE DATA	PHENOL,4-6-DIBROMO-2-(3'-4'-5'-6'-TETRABROMO-2'-HYDROXY-PHENOXY):	None
8	LIPOXYGENASE,15: INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PHENOL,3-5-DIBROMO-2-HYDROXY:	WEAK ACTIVITY
9	INOSINE MONOPHOSPHATE DEHYDROGENASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PHENOL,3-5-DIBROMO-2-HYDROXY:	INACTIVE
10	LIPOXYGENASE,15: INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PHENOL,4-6-DIBROMO-2-(3'-4'-5'-6'-TETRABROMO-2'-HYDROXY-PHENOXY):	ACTIVE
11	INOSINE MONOPHOSPHATE DEHYDROGENASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PHENOL,4-6-DIBROMO-2-(3'-4'-5'-6'-TETRABROMO-2'-HYDROXY-PHENOXY):	ACTIVE
12	PROTEIN TYROSINE KINASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PHENOL,4-6-DIBROMO-2-(3'-4'-5'-6'-TETRABROMO-2'-HYDROXY-PHENOXY):	INACTIVE
13	METALLOPROTEASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PHENOL,4-6-DIBROMO-2-(3'-4'-5'-6'-TETRABROMO-2'-HYDROXY-PHENOXY):	INACTIVE
14	GUANOSINE MONOPHOSPHATE SYNTHETASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PHENOL,4-6-DIBROMO-2-(3'-4'-5'-6'-TETRABROMO-2'-HYDROXY-PHENOXY):	WEAK ACTIVITY
15	Not specified	MASS-SPECTRAL FRAGMENTATION REPORTEDPMR SPECTRUM REPORTEDQUANTITATIVE DATAISOLATION OF A COMPOUND WITH NOVEL STRUCTURE	PHENOL,3-5-DIBROMO-2-(4'-5'-6'-TRIBROMO-2'-HYDROXY-PHENOXY):	None
16	Not specified	ISOLATION AND IDENTIFICATION OFQUANTITATIVE DATA	PHENOL,4-6-DIBROMO-2-(3'-4'-6'-TRIBROMO-2'-HYDROXY-PHENOXY):	None
17	LIPOXYGENASE,15: INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PHENOL,3-5-DIBROMO-2-(4'-5'-6'-TRIBROMO-2'-HYDROXY-PHENOXY):	WEAK ACTIVITY
18	LIPOXYGENASE,15: INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PHENOL,3-5-DIBROMO-2-(4'-5'-6'-TRIBROMO-2'-HYDROXY-PHENOXY):	ACTIVE
19	INOSINE MONOPHOSPHATE DEHYDROGENASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PHENOL,4-6-DIBROMO-2-(3'-4'-6'-TRIBROMO-2'-HYDROXY-PHENOXY):	WEAK ACTIVITY
20	PROTEIN TYROSINE KINASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PHENOL,4-6-DIBROMO-2-(3'-4'-6'-TRIBROMO-2'-HYDROXY-PHENOXY):	INACTIVE
21	METALLOPROTEASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PHENOL,4-6-DIBROMO-2-(3'-4'-6'-TRIBROMO-2'-HYDROXY-PHENOXY):	INACTIVE
22	GUANOSINE MONOPHOSPHATE SYNTHETASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PHENOL,4-6-DIBROMO-2-(3'-4'-6'-TRIBROMO-2'-HYDROXY-PHENOXY):	WEAK ACTIVITY
23	GUANOSINE MONOPHOSPHATE SYNTHETASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PHENOL,4-6-DIBROMO-2-(3'-4'-6'-TRIBROMO-2'-HYDROXY-PHENOXY):	WEAK ACTIVITY
24	Not specified	MASS-SPECTRAL FRAGMENTATION REPORTEDPMR SPECTRUM REPORTEDINFRARED SPECTRUM REPORTED FORQUANTITATIVE DATAISOLATION OF A COMPOUND WITH NOVEL STRUCTURE	PHENOL,4-6-DIBROMO-2-(4'-5'-6'-TRIBROMO-2'-HYDROXY-PHENOXY::	None
25	PROTEIN TYROSINE KINASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PHENOL,4-6-DIBROMO-2-(4'-5'-6'-TRIBROMO-2'-HYDROXY-PHENOXY::	INACTIVE
26	BETA-CHYMOTRYPSIN INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PHENOL,4-6-DIBROMO-2-(4'-5'-6'-TRIBROMO-2'-HYDROXY-PHENOXY::	INACTIVE
27	GUANOSINE MONOPHOSPHATE SYNTHETASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PHENOL,4-6-DIBROMO-2-(4'-5'-6'-TRIBROMO-2'-HYDROXY-PHENOXY::	WEAK ACTIVITY

Dysidea species (35-t-92) (DYSIDEIDAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	VOUCHER SPECIMEN REPORTED FORISOLATION AND IDENTIFICATION OFQUANTITATIVE DATA	PHENOL,3-5-DIBROMO-2-(2'-4'-DIBROMO-PHENOXY):	None
2	LIPOXYGENASE,15: INHIBITION	PHARMACOLOGY OF EXTRACT - IN VITRO	None	WEAK ACTIVITY
3	INOSINE MONOPHOSPHATE DEHYDROGENASE INHIBITION	PHARMACOLOGY OF EXTRACT - IN VITRO	None	INACTIVE
4	LIPOXYGENASE,15: INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PHENOL,3-5-DIBROMO-2-(2'-4'-DIBROMO-PHENOXY):	WEAK ACTIVITY
5	INOSINE MONOPHOSPHATE DEHYDROGENASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PHENOL,3-5-DIBROMO-2-(2'-4'-DIBROMO-PHENOXY):	ACTIVE
6	GUANOSINE MONOPHOSPHATE SYNTHETASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PHENOL,3-5-DIBROMO-2-(2'-4'-DIBROMO-PHENOXY):	WEAK ACTIVITY
7	PROTEIN TYROSINE KINASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PHENOL,3-5-DIBROMO-2-(2'-4'-DIBROMO-PHENOXY):	INACTIVE
8	METALLOPROTEASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PHENOL,3-5-DIBROMO-2-(2'-4'-DIBROMO-PHENOXY):	INACTIVE
9	Not specified	ISOLATION AND IDENTIFICATION OFMASS-SPECTRAL FRAGMENTATION REPORTEDPMR SPECTRUM REPORTEDCMR SPECTRUM REPORTEDQUANTITATIVE DATA	PHENOL,3-4-5-TRIBROMO-2-(2'-4'-DIBROMO-PHENOXY):	None
10	Not specified	ISOLATION AND IDENTIFICATION OFQUANTITATIVE DATA	PHENOL,4-6-DIBROMO-2-(2'-4'-DIBROMO-PHENOXY):	None
11	LIPOXYGENASE,15: INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PHENOL,3-4-5-TRIBROMO-2-(2'-4'-DIBROMO-PHENOXY):	WEAK ACTIVITY
12	INOSINE MONOPHOSPHATE DEHYDROGENASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PHENOL,3-4-5-TRIBROMO-2-(2'-4'-DIBROMO-PHENOXY):	ACTIVE
13	GUANOSINE MONOPHOSPHATE SYNTHETASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PHENOL,3-4-5-TRIBROMO-2-(2'-4'-DIBROMO-PHENOXY):	WEAK ACTIVITY
14	PROTEIN TYROSINE KINASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PHENOL,3-4-5-TRIBROMO-2-(2'-4'-DIBROMO-PHENOXY):	INACTIVE
15	METALLOPROTEASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PHENOL,3-4-5-TRIBROMO-2-(2'-4'-DIBROMO-PHENOXY):	INACTIVE
16	PROTEIN TYROSINE KINASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PHENOL,4-6-DIBROMO-2-(2'-4'-DIBROMO-PHENOXY):	INACTIVE
17	Not specified	ISOLATION AND IDENTIFICATION OFQUANTITATIVE DATA	PHENOL,4'-6'-DIBROMO-1'-(4-6-DIBROMO-1-METHOXY-PHENOXY):	None
18	Not specified	ISOLATION AND IDENTIFICATION OFQUANTITATIVE DATA	PHENOL,4-5-6-TRIBROMO-2-(2'-4'-DIBROMO-PHENOXY):	None
19	PROTEIN TYROSINE KINASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PHENOL,4'-6'-DIBROMO-1'-(4-6-DIBROMO-1-METHOXY-PHENOXY):	INACTIVE
20	LIPOXYGENASE,15: INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PHENOL,4-5-6-TRIBROMO-2-(2'-4'-DIBROMO-PHENOXY):	WEAK ACTIVITY
21	INOSINE MONOPHOSPHATE DEHYDROGENASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PHENOL,4-5-6-TRIBROMO-2-(2'-4'-DIBROMO-PHENOXY):	ACTIVE
22	PROTEIN TYROSINE KINASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PHENOL,4-5-6-TRIBROMO-2-(2'-4'-DIBROMO-PHENOXY):	INACTIVE
23	METALLOPROTEASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PHENOL,4-5-6-TRIBROMO-2-(2'-4'-DIBROMO-PHENOXY):	INACTIVE
24	GUANOSINE MONOPHOSPHATE SYNTHETASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PHENOL,4-5-6-TRIBROMO-2-(2'-4'-DIBROMO-PHENOXY):	WEAK ACTIVITY

Dysidea species (DYSIDEIDAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	VOUCHER SPECIMEN REPORTED FORMASS-SPECTRAL FRAGMENTATION REPORTEDPMR SPECTRUM REPORTEDCMR SPECTRUM REPORTEDISOLATION OF A COMPOUND WITH NOVEL STRUCTURE	PHENOL,4-6-DIBROMO-2-(2'-METHOXY-4'-6'-DIBROMO-PHENOXY):	None
2	PROTEIN TYROSINE KINASE INHIBITION	PHARMACOLOGY OF EXTRACT - IN VITRO	None	ACTIVE
3	PROTEIN TYROSINE KINASE INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PHENOL,4-6-DIBROMO-2-(2'-METHOXY-4'-6'-DIBROMO-PHENOXY):	INACTIVE
4	Not specified	ISOLATION AND IDENTIFICATION OF	PHENOL,4-6-DIBROMO-2-(3'-4'-5'-6'-TETRABROMO-2'-HYDROXY-PHENOXY):PHENOL,4-6-DIBROMO-2-(2'-4'-DIBROMO-PHENOXY):PHENOL,4'-6'-DIBROMO-1'-(4-6-DIBROMO-1-METHOXY-PHENOXY):	None

Dysidea species (DYSIDEIDAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	VOUCHER SPECIMEN REPORTED FORMASS-SPECTRAL FRAGMENTATION REPORTEDPMR SPECTRUM REPORTEDISOLATION OF A COMPOUND WITH NOVEL STRUCTURE	PHENOL,4-6-DIBROMO-2-(3'-4'-6'-TRIBROMO-2'-METHOXY-PHENOXY):	None
2	INOSINE MONOPHOSPHATE DEHYDROGENASE INHIBITION	PHARMACOLOGY OF EXTRACT - IN VITRO	None	ACTIVE
3	PROTEIN TYROSINE KINASE INHIBITION	PHARMACOLOGY OF EXTRACT - IN VITRO	None	ACTIVE
4	METALLOPROTEASE INHIBITION	PHARMACOLOGY OF EXTRACT - IN VITRO	None	WEAK ACTIVITY
5	Not specified	ISOLATION AND IDENTIFICATION OF	PHENOL,4-6-DIBROMO-2-(2'-METHOXY-4'-6'-DIBROMO-PHENOXY):	None
6	Not specified	ISOLATION AND IDENTIFICATION OF	PHENOL,4-6-DIBROMO-2-(3'-4'-6'-TRIBROMO-PHENOXY):	None
7	Not specified	MASS-SPECTRAL FRAGMENTATION REPORTEDPMR SPECTRUM REPORTEDISOLATION OF A COMPOUND WITH NOVEL STRUCTURE	PHENOL,4-6-DIBROMO-2-(4'-5'-6'-TRIBROMO-2'-HYDROXY-PHENOXY): 1-METHYL ETHER	None
8	Not specified	ISOLATION AND IDENTIFICATION OF	PHENOL,4-6-DIBROMO-2-(3'-4'-5'-6'-TETRABROMO-2'-HYDROXY-PHENOXY):	None

Citation 78948

Citation Details

Summary

Organisms and Their Experiments (4)

Dysidea species (5-t-92) (DYSIDEIDAE)

Dysidea species (35-t-92) (DYSIDEIDAE)

Dysidea species (DYSIDEIDAE)

Dysidea species (DYSIDEIDAE)

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