Citation 79780

ZAPF,S: WUNDER,A: ANKE,T: KLOSTERMEYER,D: STEGLICH,W: SHAN,R: STERNER,O: SCHEUER,W:. (1996). (+)-10-ALPHA-HYDROXY-4-MUUROLEN-3-ONE, A NEW INHIBITOR OF LEUKOTRIENE BIOSYNTHESIS FROM A FAVOLASCHIA SPECIES. COMPARISON WITH OTHER SESQUITERPENES.. 51(7/8)

Citation Details

Title	(+)-10-ALPHA-HYDROXY-4-MUUROLEN-3-ONE, A NEW INHIBITOR OF LEUKOTRIENE BIOSYNTHESIS FROM A FAVOLASCHIA SPECIES. COMPARISON WITH OTHER SESQUITERPENES.
Authors	ZAPF,S: WUNDER,A: ANKE,T: KLOSTERMEYER,D: STEGLICH,W: SHAN,R: STERNER,O: SCHEUER,W:
Year	1996
Volume	51
Issue	7/8

Summary

Year: 1996

Journal: Unknown

Organisms and Their Experiments (2)

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	LEUKOTRIENE C-4 INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CADINOL,T: (+):	ACTIVE
2	LEUKOTRIENE C-4 INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CADINOL,T: (+):	ACTIVE
3	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	CADINOL,T: (+):	EQUIVOCAL
4	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	CADINOL,T: (+):	EQUIVOCAL
5	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	CADINOL,T: (+):	EQUIVOCAL
6	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	CADINOL,T: (+):	EQUIVOCAL
7	LEUKOTRIENE C-4 INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CADINOL,T: 3-OXO: (+):	ACTIVE
8	LEUKOTRIENE C-4 INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CADINOL,T: 3-OXO: (+):	WEAK ACTIVITY
9	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	CADINOL,T: 3-OXO: (+):	INACTIVE
10	LEUKOTRIENE C-4 INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CADINOL,T: 3-ALPHA-HYDROXY: (+):	WEAK ACTIVITY
11	LEUKOTRIENE C-4 INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CADINOL,T: 3-ALPHA-HYDROXY: (+):	EQUIVOCAL
12	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	CADINOL,T: 3-ALPHA-HYDROXY: (+):	INACTIVE

Favolaschia species (HYPHOMYCETES)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	VOUCHER SPECIMEN REPORTED FORUV SPECTRUM GIVEN FORMASS-SPECTRAL FRAGMENTATION REPORTEDPMR SPECTRUM REPORTEDCMR SPECTRUM REPORTEDINFRARED SPECTRUM REPORTED FORQUANTITATIVE DATAISOLATION OF A COMPOUND WITH NOVEL STRUCTURECD SPECTRUM REPORTED FOR	MUUROLEN-3-ONE,4: 10-ALPHA-HYDROXY: (+):	None
2	ANTIFUNGAL ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTIBIOTIC MARKER CODE. (USE WITH 14XXX MPASPA)	MUUROLEN-3-ONE,4: 10-ALPHA-HYDROXY: (+):	INACTIVE
3	ANTIFUNGAL ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTIBIOTIC MARKER CODE. (USE WITH 14XXX MPASPA)	MUUROLEN-3-ONE,4: 10-ALPHA-HYDROXY: (+):	INACTIVE
4	ANTIFUNGAL ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTIBIOTIC MARKER CODE. (USE WITH 14XXX MPASPA)	MUUROLEN-3-ONE,4: 10-ALPHA-HYDROXY: (+):	INACTIVE
5	ANTIYEAST ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTIBIOTIC MARKER CODE. (USE WITH 14XXX MPASPA)	MUUROLEN-3-ONE,4: 10-ALPHA-HYDROXY: (+):	INACTIVE
6	ANTIFUNGAL ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTIBIOTIC MARKER CODE. (USE WITH 14XXX MPASPA)	MUUROLEN-3-ONE,4: 10-ALPHA-HYDROXY: (+):	INACTIVE
7	ANTIFUNGAL ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTIBIOTIC MARKER CODE. (USE WITH 14XXX MPASPA)	MUUROLEN-3-ONE,4: 10-ALPHA-HYDROXY: (+):	INACTIVE
8	ANTIBACTERIAL ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTIBIOTIC MARKER CODE. (USE WITH 14XXX MPASPA)	MUUROLEN-3-ONE,4: 10-ALPHA-HYDROXY: (+):	INACTIVE
9	ANTIYEAST ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTIBIOTIC MARKER CODE. (USE WITH 14XXX MPASPA)	MUUROLEN-3-ONE,4: 10-ALPHA-HYDROXY: (+):	INACTIVE
10	ANTIYEAST ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTIBIOTIC MARKER CODE. (USE WITH 14XXX MPASPA)	MUUROLEN-3-ONE,4: 10-ALPHA-HYDROXY: (+):	INACTIVE
11	ANTIBACTERIAL ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTIBIOTIC MARKER CODE. (USE WITH 14XXX MPASPA)	MUUROLEN-3-ONE,4: 10-ALPHA-HYDROXY: (+):	INACTIVE
12	ANTIBACTERIAL ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTIBIOTIC MARKER CODE. (USE WITH 14XXX MPASPA)	MUUROLEN-3-ONE,4: 10-ALPHA-HYDROXY: (+):	INACTIVE
13	ANTIBACTERIAL ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTIBIOTIC MARKER CODE. (USE WITH 14XXX MPASPA)	MUUROLEN-3-ONE,4: 10-ALPHA-HYDROXY: (+):	INACTIVE
14	ANTIBACTERIAL ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTIBIOTIC MARKER CODE. (USE WITH 14XXX MPASPA)	MUUROLEN-3-ONE,4: 10-ALPHA-HYDROXY: (+):	INACTIVE
15	ANTIBACTERIAL ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTIBIOTIC MARKER CODE. (USE WITH 14XXX MPASPA)	MUUROLEN-3-ONE,4: 10-ALPHA-HYDROXY: (+):	INACTIVE
16	ANTIBACTERIAL ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTIBIOTIC MARKER CODE. (USE WITH 14XXX MPASPA)	MUUROLEN-3-ONE,4: 10-ALPHA-HYDROXY: (+):	INACTIVE
17	ANTIBACTERIAL ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTIBIOTIC MARKER CODE. (USE WITH 14XXX MPASPA)	MUUROLEN-3-ONE,4: 10-ALPHA-HYDROXY: (+):	INACTIVE
18	ANTIBACTERIAL ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTIBIOTIC MARKER CODE. (USE WITH 14XXX MPASPA)	MUUROLEN-3-ONE,4: 10-ALPHA-HYDROXY: (+):	INACTIVE
19	ANTIBACTERIAL ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTIBIOTIC MARKER CODE. (USE WITH 14XXX MPASPA)	MUUROLEN-3-ONE,4: 10-ALPHA-HYDROXY: (+):	INACTIVE
20	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	MUUROLEN-3-ONE,4: 10-ALPHA-HYDROXY: (+):	INACTIVE
21	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	MUUROLEN-3-ONE,4: 10-ALPHA-HYDROXY: (+):	INACTIVE
22	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	MUUROLEN-3-ONE,4: 10-ALPHA-HYDROXY: (+):	INACTIVE
23	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	MUUROLEN-3-ONE,4: 10-ALPHA-HYDROXY: (+):	INACTIVE
24	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	MUUROLEN-3-ONE,4: 10-ALPHA-HYDROXY: (+):	INACTIVE
25	LEUKOTRIENE C-4 INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	MUUROLEN-3-ONE,4: 10-ALPHA-HYDROXY: (+):	ACTIVE
26	LEUKOTRIENE C-4 INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	MUUROLEN-3-ONE,4: 10-ALPHA-HYDROXY: (+):	WEAK ACTIVITY