Citation 80965

ISSHIKI,K: NISHIO,M: SAKURAI,N: UCHIDA,T: OKUDA,T: KOMATSUBARA,S:. (1998). TMC-52A TO D, NOVEL CYSTEINE PROTEINASE INHIBITORS, PRODUCED BY GLIOCLADIUM SP.. 51(7)

Citation Details

TitleTMC-52A TO D, NOVEL CYSTEINE PROTEINASE INHIBITORS, PRODUCED BY GLIOCLADIUM SP.
AuthorsISSHIKI,K: NISHIO,M: SAKURAI,N: UCHIDA,T: OKUDA,T: KOMATSUBARA,S:
Year1998
Volume51
Issue7

Summary

Year: 1998

Journal: Unknown

Organisms and Their Experiments (1)

Gliocladium species (HYPHOMYCETES)

Experiment #Pharmacology TypeWorktypesCompoundResults
1Not specified
UV SPECTRUM GIVEN FORMASS-SPECTRAL FRAGMENTATION REPORTEDPMR SPECTRUM REPORTEDCMR SPECTRUM REPORTEDINFRARED SPECTRUM REPORTED FORQUANTITATIVE DATAISOLATION OF A COMPOUND WITH NOVEL STRUCTURE
GLIOCLADIUM ANTIBIOTIC TMC-52-A
None
2
CATHEPSIN L INHIBITION
PHARMACOLOGY OF COMPOUND - IN VITRO
GLIOCLADIUM ANTIBIOTIC TMC-52-A
ACTIVE
3
CATHEPSIN B INHIBITION
PHARMACOLOGY OF COMPOUND - IN VITRO
GLIOCLADIUM ANTIBIOTIC TMC-52-A
ACTIVE
4
PAPAIN INHIBITION
PHARMACOLOGY OF COMPOUND - IN VITRO
GLIOCLADIUM ANTIBIOTIC TMC-52-A
ACTIVE
5
CALPAIN(M) INHIBITION
PHARMACOLOGY OF COMPOUND - IN VITRO
GLIOCLADIUM ANTIBIOTIC TMC-52-A
WEAK ACTIVITY
6
CALPAIN(MU) INHIBITION
PHARMACOLOGY OF COMPOUND - IN VITRO
GLIOCLADIUM ANTIBIOTIC TMC-52-A
WEAK ACTIVITY
7
TRYPSIN INHIBITION
PHARMACOLOGY OF COMPOUND - IN VITRO
GLIOCLADIUM ANTIBIOTIC TMC-52-A
INACTIVE
8
THERMOLYSIN INHIBITION
PHARMACOLOGY OF COMPOUND - IN VITRO
GLIOCLADIUM ANTIBIOTIC TMC-52-A
INACTIVE
9
CATHEPSIN D INHIBITION
PHARMACOLOGY OF COMPOUND - IN VITRO
GLIOCLADIUM ANTIBIOTIC TMC-52-A
INACTIVE
10Not specified
UV SPECTRUM GIVEN FORMASS-SPECTRAL FRAGMENTATION REPORTEDPMR SPECTRUM REPORTEDCMR SPECTRUM REPORTEDINFRARED SPECTRUM REPORTED FORQUANTITATIVE DATAISOLATION OF A COMPOUND WITH NOVEL STRUCTURE
GLIOCLADIUM ANTIBIOTIC TMC-52-B
None
11
CATHEPSIN L INHIBITION
PHARMACOLOGY OF COMPOUND - IN VITRO
GLIOCLADIUM ANTIBIOTIC TMC-52-B
ACTIVE
12
CATHEPSIN B INHIBITION
PHARMACOLOGY OF COMPOUND - IN VITRO
GLIOCLADIUM ANTIBIOTIC TMC-52-B
ACTIVE
13
PAPAIN INHIBITION
PHARMACOLOGY OF COMPOUND - IN VITRO
GLIOCLADIUM ANTIBIOTIC TMC-52-B
STRONG ACTIVITY
14
GLUCAN FORMATION INHIBITION
PHARMACOLOGY OF COMPOUND - IN VITRO
GLIOCLADIUM ANTIBIOTIC TMC-52-B
WEAK ACTIVITY
15
CALPAIN(MU) INHIBITION
PHARMACOLOGY OF COMPOUND - IN VITRO
GLIOCLADIUM ANTIBIOTIC TMC-52-B
WEAK ACTIVITY
16
TRYPSIN INHIBITION
PHARMACOLOGY OF COMPOUND - IN VITRO
GLIOCLADIUM ANTIBIOTIC TMC-52-B
INACTIVE
17
THERMOLYSIN INHIBITION
PHARMACOLOGY OF COMPOUND - IN VITRO
GLIOCLADIUM ANTIBIOTIC TMC-52-B
INACTIVE
18
CATHEPSIN D INHIBITION
PHARMACOLOGY OF COMPOUND - IN VITRO
GLIOCLADIUM ANTIBIOTIC TMC-52-B
INACTIVE
19Not specified
UV SPECTRUM GIVEN FORMASS-SPECTRAL FRAGMENTATION REPORTEDPMR SPECTRUM REPORTEDCMR SPECTRUM REPORTEDINFRARED SPECTRUM REPORTED FORQUANTITATIVE DATAISOLATION OF A COMPOUND WITH NOVEL STRUCTURE
GLIOCLADIUM ANTIBIOTIC TMC-52-C
None
20
CATHEPSIN L INHIBITION
PHARMACOLOGY OF COMPOUND - IN VITRO
GLIOCLADIUM ANTIBIOTIC TMC-52-C
ACTIVE
21
CATHEPSIN B INHIBITION
PHARMACOLOGY OF COMPOUND - IN VITRO
GLIOCLADIUM ANTIBIOTIC TMC-52-C
ACTIVE
22
PAPAIN INHIBITION
PHARMACOLOGY OF COMPOUND - IN VITRO
GLIOCLADIUM ANTIBIOTIC TMC-52-C
ACTIVE
23
CALPAIN(M) INHIBITION
PHARMACOLOGY OF COMPOUND - IN VITRO
GLIOCLADIUM ANTIBIOTIC TMC-52-C
WEAK ACTIVITY
24
CALPAIN(MU) INHIBITION
PHARMACOLOGY OF COMPOUND - IN VITRO
GLIOCLADIUM ANTIBIOTIC TMC-52-C
WEAK ACTIVITY
25
TRYPSIN INHIBITION
PHARMACOLOGY OF COMPOUND - IN VITRO
GLIOCLADIUM ANTIBIOTIC TMC-52-C
INACTIVE
26
THERMOLYSIN INHIBITION
PHARMACOLOGY OF COMPOUND - IN VITRO
GLIOCLADIUM ANTIBIOTIC TMC-52-C
INACTIVE
27
CATHEPSIN D INHIBITION
PHARMACOLOGY OF COMPOUND - IN VITRO
GLIOCLADIUM ANTIBIOTIC TMC-52-C
INACTIVE
28Not specified
UV SPECTRUM GIVEN FORMASS-SPECTRAL FRAGMENTATION REPORTEDPMR SPECTRUM REPORTEDCMR SPECTRUM REPORTEDINFRARED SPECTRUM REPORTED FORQUANTITATIVE DATAISOLATION OF A COMPOUND WITH NOVEL STRUCTURE
CLIOCLADIUM ANTIBIOTIC TMC-52-D
None
29
CATHEPSIN L INHIBITION
PHARMACOLOGY OF COMPOUND - IN VITRO
CLIOCLADIUM ANTIBIOTIC TMC-52-D
STRONG ACTIVITY
30
CATHEPSIN B INHIBITION
PHARMACOLOGY OF COMPOUND - IN VITRO
CLIOCLADIUM ANTIBIOTIC TMC-52-D
ACTIVE
31
PAPAIN INHIBITION
PHARMACOLOGY OF COMPOUND - IN VITRO
CLIOCLADIUM ANTIBIOTIC TMC-52-D
ACTIVE
32
CALPAIN(M) INHIBITION
PHARMACOLOGY OF COMPOUND - IN VITRO
CLIOCLADIUM ANTIBIOTIC TMC-52-D
WEAK ACTIVITY
33
CALPAIN(MU) INHIBITION
PHARMACOLOGY OF COMPOUND - IN VITRO
CLIOCLADIUM ANTIBIOTIC TMC-52-D
WEAK ACTIVITY
34
TRYPSIN INHIBITION
PHARMACOLOGY OF COMPOUND - IN VITRO
CLIOCLADIUM ANTIBIOTIC TMC-52-D
INACTIVE
35
THERMOLYSIN INHIBITION
PHARMACOLOGY OF COMPOUND - IN VITRO
CLIOCLADIUM ANTIBIOTIC TMC-52-D
INACTIVE
36
CATHEPSIN D INHIBITION
PHARMACOLOGY OF COMPOUND - IN VITRO
CLIOCLADIUM ANTIBIOTIC TMC-52-D
INACTIVE
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