Citation 81617

HARRIGAN,GG: YOSHIDA,WY: MOORE,RE: NAGLE,DG: PARK,PU: BIGGS,J: PAUL,V: MOOBERRY,SL: CORBETT,TH: VALERIOTE,FA:. (1998). ISOLATION, STRUCTURE DETERMINATION, AND BIOLOGICAL ACTIVITY OF DOLASTATIN 12 AND LYNGBYASTATIN 1 FROM LYNGBYA MAJUSCULA/SCHIZOTHRIX CALCICOLA CYANOBACTERIAL ASSEMBLAGES.. 61(10)

Citation Details

Title	ISOLATION, STRUCTURE DETERMINATION, AND BIOLOGICAL ACTIVITY OF DOLASTATIN 12 AND LYNGBYASTATIN 1 FROM LYNGBYA MAJUSCULA/SCHIZOTHRIX CALCICOLA CYANOBACTERIAL ASSEMBLAGES.
Authors	HARRIGAN,GG: YOSHIDA,WY: MOORE,RE: NAGLE,DG: PARK,PU: BIGGS,J: PAUL,V: MOOBERRY,SL: CORBETT,TH: VALERIOTE,FA:
Year	1998
Volume	61
Issue	10

Summary

Year: 1998

Journal: Unknown

Organisms and Their Experiments (2)

Lyngbya majuscula (OSCILLATORIACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	AMINO ACID ANALYSIS OFMASS-SPECTRAL FRAGMENTATION REPORTEDPMR SPECTRUM REPORTEDISOLATION OF A COMPOUND WITH NOVEL STRUCTURE	LYNGBYASTATIN 1	None
2	MICROFILAMENT DISRUPTION	PHARMACOLOGY OF COMPOUND - IN VITRO	LYNGBYASTATIN 1LYNGBYASTATIN 1,15-EPI:	ACTIVE
3	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	LYNGBYASTATIN 1LYNGBYASTATIN 1,15-EPI:	WEAK ACTIVITY
4	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	LYNGBYASTATIN 1LYNGBYASTATIN 1,15-EPI:	WEAK ACTIVITY
5	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	LYNGBYASTATIN 1LYNGBYASTATIN 1,15-EPI:	WEAK ACTIVITY
6	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	LYNGBYASTATIN 1LYNGBYASTATIN 1,15-EPI:	WEAK ACTIVITY
7	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	LYNGBYASTATIN 1LYNGBYASTATIN 1,15-EPI:	WEAK ACTIVITY
8	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	LYNGBYASTATIN 1LYNGBYASTATIN 1,15-EPI:	ACTIVE
9	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	LYNGBYASTATIN 1LYNGBYASTATIN 1,15-EPI:	ACTIVE
10	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVO	LYNGBYASTATIN 1LYNGBYASTATIN 1,15-EPI:	INACTIVE
11	TOXIC EFFECT(UNSPEC)	PHARMACOLOGY OF COMPOUND - IN VIVO	LYNGBYASTATIN 1LYNGBYASTATIN 1,15-EPI:	ACTIVE
12	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVO	LYNGBYASTATIN 1LYNGBYASTATIN 1,15-EPI:	INACTIVE
13	Not specified	MASS-SPECTRAL FRAGMENTATION REPORTEDPMR SPECTRUM REPORTEDISOLATION OF A COMPOUND WITH NOVEL STRUCTURE	LYNGBYASTATIN 1,15-EPI:	None

Schizothrix calcicola (OSCILLATORIACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	AMINO ACID ANALYSIS OFISOLATION AND IDENTIFICATION OFMASS-SPECTRAL FRAGMENTATION REPORTEDPMR SPECTRUM REPORTED	DOLASTATIN 12DOLASTATIN 12,EPI:	None
2	MICROFILAMENT DISRUPTION	PHARMACOLOGY OF COMPOUND - IN VITRO	DOLASTATIN 12DOLASTATIN 12,EPI:	ACTIVE
3	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	DOLASTATIN 12DOLASTATIN 12,EPI:	WEAK ACTIVITY
4	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	DOLASTATIN 12DOLASTATIN 12,EPI:	WEAK ACTIVITY
5	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	DOLASTATIN 12DOLASTATIN 12,EPI:	WEAK ACTIVITY
6	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	DOLASTATIN 12DOLASTATIN 12,EPI:	WEAK ACTIVITY
7	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	DOLASTATIN 12DOLASTATIN 12,EPI:	WEAK ACTIVITY
8	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	DOLASTATIN 12DOLASTATIN 12,EPI:	ACTIVE
9	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	DOLASTATIN 12DOLASTATIN 12,EPI:	ACTIVE
10	TOXIC EFFECT(UNSPEC)	PHARMACOLOGY OF COMPOUND - IN VIVO	DOLASTATIN 12DOLASTATIN 12,EPI:	ACTIVE
11	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVO	DOLASTATIN 12DOLASTATIN 12,EPI:	INACTIVE
12	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVO	DOLASTATIN 12DOLASTATIN 12,EPI:	INACTIVE