Citation 97707

EVANS,FJ: KINGHORN,AD: SCHMIDT,RJ:. (1975). SOME NATURALLY OCCURRING SKIN IRRITANTS.. 37()

Citation Details

Title	SOME NATURALLY OCCURRING SKIN IRRITANTS.
Authors	EVANS,FJ: KINGHORN,AD: SCHMIDT,RJ:
Year	1975
Volume	37
Issue

Summary

Year: 1975

Journal: Unknown

Organisms and Their Experiments (4)

Euphorbia fortissima (EUPHORBIACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	IRRITANT ACTIVITY	TOXICITY MARKER CODEISOLATION AND IDENTIFICATION OFPHARMACOLOGY OF COMPOUND - IN VIVOSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODEYIELD IS LESS THAN 50 MGMCARCINOGENIC DATA (MARKER CODE)	PHORBOL,12-DEOXY: 13-O-TIGLATE-20-ACETATE	ACTIVE
2	IRRITANT ACTIVITY	TOXICITY MARKER CODEISOLATION AND IDENTIFICATION OFPHARMACOLOGY OF COMPOUND - IN VIVOSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODEYIELD IS LESS THAN 50 MGMCARCINOGENIC DATA (MARKER CODE)	PHORBOL,12-DEOXY: 13-O-TIGLATE-20-ACETATE	ACTIVE
3	IRRITANT ACTIVITY	TOXICITY MARKER CODEISOLATION AND IDENTIFICATION OFPHARMACOLOGY OF COMPOUND - IN VIVOSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODEYIELD IS LESS THAN 50 MGMCARCINOGENIC DATA (MARKER CODE)	PHORBOL,12-DEOXY: 13-O-TIGLATE	ACTIVE
4	IRRITANT ACTIVITY	TOXICITY MARKER CODEISOLATION AND IDENTIFICATION OFPHARMACOLOGY OF COMPOUND - IN VIVOSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODEYIELD IS LESS THAN 50 MGMCARCINOGENIC DATA (MARKER CODE)	PHORBOL,12-DEOXY: 13-O-TIGLATE	ACTIVE
5	IRRITANT ACTIVITY	TOXICITY MARKER CODEISOLATION AND IDENTIFICATION OFPHARMACOLOGY OF COMPOUND - IN VIVOSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODEYIELD IS LESS THAN 50 MGMCARCINOGENIC DATA (MARKER CODE)	PHORBOL,12-DEOXY: 13-O-ISO-BUTYRATE-20-ACETATE	ACTIVE
6	IRRITANT ACTIVITY	TOXICITY MARKER CODEISOLATION AND IDENTIFICATION OFPHARMACOLOGY OF COMPOUND - IN VIVOSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODEYIELD IS LESS THAN 50 MGMCARCINOGENIC DATA (MARKER CODE)	PHORBOL,12-DEOXY: 13-O-ISO-BUTYRATE-20-ACETATE	ACTIVE
7	IRRITANT ACTIVITY	TOXICITY MARKER CODEISOLATION AND IDENTIFICATION OFPHARMACOLOGY OF COMPOUND - IN VIVOSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODEYIELD IS LESS THAN 50 MGMCARCINOGENIC DATA (MARKER CODE)	PHORBOL,12-DEOXY: 13-(2-METHYL-BUTYRATE)-20-ACETATE	ACTIVE
8	IRRITANT ACTIVITY	TOXICITY MARKER CODEISOLATION AND IDENTIFICATION OFPHARMACOLOGY OF COMPOUND - IN VIVOSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODEYIELD IS LESS THAN 50 MGMCARCINOGENIC DATA (MARKER CODE)	PHORBOL,12-DEOXY: 13-(2-METHYL-BUTYRATE)-20-ACETATE	ACTIVE
9	IRRITANT ACTIVITY	TOXICITY MARKER CODEMASS-SPECTRAL FRAGMENTATION REPORTEDPHARMACOLOGY OF COMPOUND - IN VIVOSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODEISOLATION OF A COMPOUND WITH NOVEL STRUCTUREYIELD IS LESS THAN 50 MGMCARCINOGENIC DATA (MARKER CODE)	PHORBOL,12-DEOXY: 13-DODECENOATE-20-ACETATE	ACTIVE
10	IRRITANT ACTIVITY	TOXICITY MARKER CODEMASS-SPECTRAL FRAGMENTATION REPORTEDPHARMACOLOGY OF COMPOUND - IN VIVOSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODEISOLATION OF A COMPOUND WITH NOVEL STRUCTUREYIELD IS LESS THAN 50 MGMCARCINOGENIC DATA (MARKER CODE)	PHORBOL,12-DEOXY: 13-DODECENOATE-20-ACETATE	ACTIVE
11	IRRITANT ACTIVITY	TOXICITY MARKER CODEMASS-SPECTRAL FRAGMENTATION REPORTEDPHARMACOLOGY OF COMPOUND - IN VIVOSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODEISOLATION OF A COMPOUND WITH NOVEL STRUCTUREYIELD IS LESS THAN 50 MGMCARCINOGENIC DATA (MARKER CODE)	PHORBOL,12-DEOXY: 13-DODECENOATE	ACTIVE
12	IRRITANT ACTIVITY	TOXICITY MARKER CODEMASS-SPECTRAL FRAGMENTATION REPORTEDPHARMACOLOGY OF COMPOUND - IN VIVOSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODEISOLATION OF A COMPOUND WITH NOVEL STRUCTUREYIELD IS LESS THAN 50 MGMCARCINOGENIC DATA (MARKER CODE)	PHORBOL,12-DEOXY: 13-DODECENOATE	ACTIVE

Euphorbia helioscopia (EUPHORBIACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	IRRITANT ACTIVITY	TOXICITY MARKER CODEISOLATION AND IDENTIFICATION OFPHARMACOLOGY OF COMPOUND - IN VIVOSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODEYIELD IS LESS THAN 50 MGMCARCINOGENIC DATA (MARKER CODE)	PHORBOL,12-DEOXY: 13-O-TIGLATE-20-ACETATE	ACTIVE
2	IRRITANT ACTIVITY	TOXICITY MARKER CODEISOLATION AND IDENTIFICATION OFPHARMACOLOGY OF COMPOUND - IN VIVOSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODEYIELD IS LESS THAN 50 MGMCARCINOGENIC DATA (MARKER CODE)	PHORBOL,12-DEOXY: 13-O-TIGLATE-20-ACETATE	ACTIVE
3	IRRITANT ACTIVITY	TOXICITY MARKER CODEISOLATION AND IDENTIFICATION OFPHARMACOLOGY OF COMPOUND - IN VIVOSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODEYIELD IS LESS THAN 50 MGMCARCINOGENIC DATA (MARKER CODE)	PHORBOL,12-DEOXY: 13-O-TIGLATE	ACTIVE
4	IRRITANT ACTIVITY	TOXICITY MARKER CODEISOLATION AND IDENTIFICATION OFPHARMACOLOGY OF COMPOUND - IN VIVOSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODEYIELD IS LESS THAN 50 MGMCARCINOGENIC DATA (MARKER CODE)	PHORBOL,12-DEOXY: 13-O-TIGLATE	ACTIVE
5	IRRITANT ACTIVITY	TOXICITY MARKER CODEMASS-SPECTRAL FRAGMENTATION REPORTEDPHARMACOLOGY OF COMPOUND - IN VIVOSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODEISOLATION OF A COMPOUND WITH NOVEL STRUCTUREYIELD IS LESS THAN 50 MGMCARCINOGENIC DATA (MARKER CODE)	PHORBOL,12-DEOXY: 13-DODECADIENOATE-20-ACETATE	ACTIVE
6	IRRITANT ACTIVITY	TOXICITY MARKER CODEMASS-SPECTRAL FRAGMENTATION REPORTEDPHARMACOLOGY OF COMPOUND - IN VIVOSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODEISOLATION OF A COMPOUND WITH NOVEL STRUCTUREYIELD IS LESS THAN 50 MGMCARCINOGENIC DATA (MARKER CODE)	PHORBOL,12-DEOXY: 13-DODECADIENOATE-20-ACETATE	ACTIVE

Euphorbia caerulescens (EUPHORBIACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	IRRITANT ACTIVITY	TOXICITY MARKER CODEISOLATION AND IDENTIFICATION OFPHARMACOLOGY OF COMPOUND - IN VIVOSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODEYIELD IS LESS THAN 50 MGMCARCINOGENIC DATA (MARKER CODE)	PHORBOL,12-DEOXY: 13-O-TIGLATE-20-ACETATE	ACTIVE
2	IRRITANT ACTIVITY	TOXICITY MARKER CODEISOLATION AND IDENTIFICATION OFPHARMACOLOGY OF COMPOUND - IN VIVOSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODEYIELD IS LESS THAN 50 MGMCARCINOGENIC DATA (MARKER CODE)	PHORBOL,12-DEOXY: 13-O-TIGLATE-20-ACETATE	ACTIVE
3	IRRITANT ACTIVITY	TOXICITY MARKER CODEISOLATION AND IDENTIFICATION OFPHARMACOLOGY OF COMPOUND - IN VIVOSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODEYIELD IS LESS THAN 50 MGMCARCINOGENIC DATA (MARKER CODE)	PHORBOL,12-DEOXY: 13-(2-METHYL-BUTYRATE)-20-ACETATE	ACTIVE
4	IRRITANT ACTIVITY	TOXICITY MARKER CODEISOLATION AND IDENTIFICATION OFPHARMACOLOGY OF COMPOUND - IN VIVOSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODEYIELD IS LESS THAN 50 MGMCARCINOGENIC DATA (MARKER CODE)	PHORBOL,12-DEOXY: 13-(2-METHYL-BUTYRATE)-20-ACETATE	ACTIVE
5	IRRITANT ACTIVITY	TOXICITY MARKER CODEISOLATION AND IDENTIFICATION OFPHARMACOLOGY OF COMPOUND - IN VIVOSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODEYIELD IS LESS THAN 50 MGMCARCINOGENIC DATA (MARKER CODE)	PHORBOL,12-DEOXY: 13-(2-METHYL-BUTYRATE)	ACTIVE
6	IRRITANT ACTIVITY	TOXICITY MARKER CODEISOLATION AND IDENTIFICATION OFPHARMACOLOGY OF COMPOUND - IN VIVOSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODEYIELD IS LESS THAN 50 MGMCARCINOGENIC DATA (MARKER CODE)	PHORBOL,12-DEOXY: 13-(2-METHYL-BUTYRATE)	ACTIVE
7	IRRITANT ACTIVITY	TOXICITY MARKER CODEMASS-SPECTRAL FRAGMENTATION REPORTEDPHARMACOLOGY OF COMPOUND - IN VIVOSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODEISOLATION OF A COMPOUND WITH NOVEL STRUCTUREYIELD IS LESS THAN 50 MGMCARCINOGENIC DATA (MARKER CODE)	PHORBOL,12-DEOXY: 13-HEPTANOATE	ACTIVE
8	IRRITANT ACTIVITY	TOXICITY MARKER CODEMASS-SPECTRAL FRAGMENTATION REPORTEDPHARMACOLOGY OF COMPOUND - IN VIVOSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODEISOLATION OF A COMPOUND WITH NOVEL STRUCTUREYIELD IS LESS THAN 50 MGMCARCINOGENIC DATA (MARKER CODE)	PHORBOL,12-DEOXY: 13-HEPTANOATE	ACTIVE
9	IRRITANT ACTIVITY	TOXICITY MARKER CODEMASS-SPECTRAL FRAGMENTATION REPORTEDPMR SPECTRUM REPORTEDPHARMACOLOGY OF COMPOUND - IN VIVOSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODEISOLATION OF A COMPOUND WITH NOVEL STRUCTUREYIELD IS LESS THAN 50 MGMCARCINOGENIC DATA (MARKER CODE)	PHORBOL,12-DEOXY: 13-DODECANOATE-20-ACETATE	ACTIVE
10	IRRITANT ACTIVITY	TOXICITY MARKER CODEMASS-SPECTRAL FRAGMENTATION REPORTEDPMR SPECTRUM REPORTEDPHARMACOLOGY OF COMPOUND - IN VIVOSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODEISOLATION OF A COMPOUND WITH NOVEL STRUCTUREYIELD IS LESS THAN 50 MGMCARCINOGENIC DATA (MARKER CODE)	PHORBOL,12-DEOXY: 13-DODECANOATE-20-ACETATE	ACTIVE
11	IRRITANT ACTIVITY	TOXICITY MARKER CODEMASS-SPECTRAL FRAGMENTATION REPORTEDPMR SPECTRUM REPORTEDPHARMACOLOGY OF COMPOUND - IN VIVOSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODEISOLATION OF A COMPOUND WITH NOVEL STRUCTUREYIELD IS LESS THAN 50 MGMCARCINOGENIC DATA (MARKER CODE)	PHORBOL,12-DEOXY: 13-DODECANOATE	ACTIVE
12	IRRITANT ACTIVITY	TOXICITY MARKER CODEMASS-SPECTRAL FRAGMENTATION REPORTEDPMR SPECTRUM REPORTEDPHARMACOLOGY OF COMPOUND - IN VIVOSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODEISOLATION OF A COMPOUND WITH NOVEL STRUCTUREYIELD IS LESS THAN 50 MGMCARCINOGENIC DATA (MARKER CODE)	PHORBOL,12-DEOXY: 13-DODECANOATE	ACTIVE

Euphorbia polyacantha (EUPHORBIACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	IRRITANT ACTIVITY	TOXICITY MARKER CODEMASS-SPECTRAL FRAGMENTATION REPORTEDPHARMACOLOGY OF COMPOUND - IN VIVOSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODEISOLATION OF A COMPOUND WITH NOVEL STRUCTUREYIELD IS LESS THAN 50 MGMCARCINOGENIC DATA (MARKER CODE)	PHORBOL,12-DEOXY: 13-OCTENOATE-20-ACETATE	ACTIVE
2	IRRITANT ACTIVITY	TOXICITY MARKER CODEMASS-SPECTRAL FRAGMENTATION REPORTEDPHARMACOLOGY OF COMPOUND - IN VIVOSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODEISOLATION OF A COMPOUND WITH NOVEL STRUCTUREYIELD IS LESS THAN 50 MGMCARCINOGENIC DATA (MARKER CODE)	PHORBOL,12-DEOXY: 13-OCTENOATE-20-ACETATE	ACTIVE
3	IRRITANT ACTIVITY	TOXICITY MARKER CODEMASS-SPECTRAL FRAGMENTATION REPORTEDPHARMACOLOGY OF COMPOUND - IN VIVOSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODEISOLATION OF A COMPOUND WITH NOVEL STRUCTUREYIELD IS LESS THAN 50 MGMCARCINOGENIC DATA (MARKER CODE)	PHORBOL,12-DEOXY: 13-DECADIENOATE-20-ACETATE	ACTIVE
4	IRRITANT ACTIVITY	TOXICITY MARKER CODEMASS-SPECTRAL FRAGMENTATION REPORTEDPHARMACOLOGY OF COMPOUND - IN VIVOSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODEISOLATION OF A COMPOUND WITH NOVEL STRUCTUREYIELD IS LESS THAN 50 MGMCARCINOGENIC DATA (MARKER CODE)	PHORBOL,12-DEOXY: 13-DECADIENOATE-20-ACETATE	ACTIVE

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