Experiment 1005232

Details

PropertyValue
Pharmacology
Administration routeIM
OrganismEmpty organism
CitationPOWLES,R: CLINK,HM: SPENCE,D: MORGENSTERN,G: WATSON,JG: SELBY,PJ: WOODS,M: BARRETT,A: JAMESON,B: SLOANE,J: LAWLER,SD: KAY,HEM: LAWSON,D: MC ELWAIN,TJ:. (1980). CYCLOSPORIN A TO PREVENT GRAFT-VERSUS-HOST DISEASE IN MAN AFTER ALLOGENEIC BONE-MARROW TRANSPLANTATION.. 1980()
Amount utilized
Compound isolated
DiseaseUSE IN 23 CASES OF ALLOGENIC BONE-MARROW TRANSPLANT,21 WITH ACUTE LEUKEMIA,ONE WITH CHRONIC GRANULOCYTIC LEUKEMIA AND ONE WITH APLASTIC ANEMIA. DOSING WAS IN TWO 12 HOURLY DOSES STARTING 24 HURS BEFORE THE INFUSION OF MARROW AND CONTINUED FOR FIVE DAYS. FROM THE SIXTH DAY THE DRUG WAS GIVEN ORALLY (12 MG/KG/DAY IN 2 TWELVE HOURLY DOSES) DOSING WAS IN TWO 12 HOURLY DOSES STARTING 24 HOURS BEFORE THE INFUSION OF MARROW WAS CONTINUED FOR FIVE DAYS. FROM THE SIXTH DAY THE DRUG WAS GIVEN ORALLY (12 MG/KG/DAY IN 2 TWELEVE HOURLY DOSES).
Dose amount25.0 MG
Number1
Qualitative resultACTIVE
AnimalHUMAN ADULT
Per unitKG
Dose expressionDOSE
GenderGIVEN TO BOTH SEXES