Experiment 1016735
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Empty organism |
| Citation | NEWMAN,KN: MEEKS,RG: FERRELL,JF: GREENSPUN,KS:. (1982). INTRAVENOUS (IV) TOXICITY STUDY OF HOMOHARRINGTONINE (HH) (NSC 141633) IN CDF-1 MICE AND BEAGLE DOGS.. 2(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | GASTROINTESTINAL(EMESIS,HEMORRHAGIC DIARRHEA),CARDIAC(TACHYCARDIA,PREMATURE VENTRICULAR CONTRACTIONS,VENTRICULAR ARRHYTHMIAS),BONE MARROW (GRANULOCYTOPENIA),AND LYMPHATIC(LYMPHOCYTOPENIA)TOXICITY WAS OBSERVED ON SINGLE OR X 5 DOSING LIVER AND KIDNEY DAMAGE(ELEVATED SGOT,SGPT,SAP AND BUN) AND ELECTROLYTE IMBALANCES WERE SEEN. HISTOPATHOLOGICAL CHANGES WERE SEEN IN THE LYMPHOID SYSTEM,MARROW,G.I.TRACT AND KIDNEYS. |
| Dose amount | 12.8 MG |
| Number | 10 |
| Qualitative result | ACTIVE |
| Animal | DOG(BEAGLE) |
| Per unit | SQ M BODY SURFACE |
| Dose expression | DOSE |