Experiment 1017814

Details

PropertyValue
Pharmacology
Administration routeIV
OrganismEmpty organism
CitationTANG,XC: WANG,YE: FENG,J: ZHANG,YL: ZHUANG,DL:. (1982). DISPOSITION OF (3H)-DIMETHYL-L-CURINE DIMETHOCHLORIDE IN RATS.. 3()
Amount utilized
Compound isolated
DiseaseTESTED AS (3H)-DIMETHYL-L-CURINE DIMETHOCHLORIDE. AFTER AN IV BOLUS, THE COMPOUND DISAPPEARED FROM THE BLOOD IN A MANNER BEST FITTING A TRIEXPONENTIAL MODEL. THE DATA IMPLIED THAT THECOMPOUND DISTRIBUTED WIDELY, PASSED QUICKLY INTO PERIPHERAL COMPARTMENTS AND WAS ELIMINATED AT A SLOWER RATE. RADIOACTIVITY LEVELS WERE HIGHES IN KIDNEY AND MODERATE IN LIVER,LUNG AND SKELETAL MUSCLE. ONLY TRACES WERE FOUND IN FAT AND BRAIN. 48-72% WAS EXCRETD IN URINE AND 5.3% IN FECES IN 24 HOURS. ABOUT 13% OF THE NO METABOLITES WERE DETECTED IN URINE OR BILE.
Dose amount375.0 MICROCURIES
Number1
Qualitative resultACTIVE
AnimalRAT
Per unitKG
Dose expressionDOSE