Experiment 1018954

Details

PropertyValue
Pharmacology
Administration routeEXTERNAL
OrganismPodophyllum peltatum (BERBERIDACEAE)
CitationKAROL,MD: CONNER,CS: WATANABE,AS: MURPHREY,KJ:. (1980). PODOPHYLLUM: SUSPECTED TERATOGENICITY FROM TOPICAL APPLICATION.. 16()
Amount utilized
Compound isolated
DiseaseA 27 YEAR OLD FEMALE RECEIVED TOPICAL APPLICATION OF PODOPHYLLUM RESIN AT THE END OF THE 23RD,24TH,25TH,28TH AND 29TH WEEKS OF PREGNANCY FOR TREATMENT OF CODYLOMATA ACUMINATA. THE RESIN WAS LEFT IN PLACE AFTER EACH APPLICATION FOR A DURATION OF 4 HRS AND THEN WASHED OFF. THE PATIENT ALSO RECEIVED CHLOROQUINE,TWO TABLETS WEEKLY ON SUNDAY,FROM CA. 19 WKS PRE-PREGNANCY THROUGH THE 21ST WK OF PREGNANCY(40 WKS), PROPHYLACTICALLY DUE TO EXPOSURE TO MALARIA. IN ADDITION, PRIMAQUINE PHOSPHATE, ONE TABLET DAILY, WAS ADMINISTERED DURING THE 22ND WK OF PREGNANCY. THE PATIENT GAVE BIRTH TO A 2.78 KG FEMALE. AT BIRTH, MINOR ANOMALIES WERE NOTED INCLUDING PREAURICULAR SKIN TAGS AND ASSIMIAN CREASE ON THE LEFT HAND. IN ADDITION, A GRADE ONE OUT OF SIX SYSTOLIC EJECTION MURMUR WAS DETECTED AT THE LEFT STERNUM BORDER WHICH SUBSEQUENTLY SUBSIDED. BOTH MOTHER AND CHILD HAD RH NEGATIVE BLOOD TYPES. A DISCUSSION OF LITERATURE ON THE USE AND TOXICITY OF PODOPHYLLUM RESIN IS PRESENTED(14 REFERENCES).
Dose amount25.0%
Number1
Qualitative resultACTIVE
AnimalHUMAN(PREGNANT)
Dose expressionCONC USED
ExtractTINCTURE