Experiment 1020498
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | SC |
| Organism | Empty organism |
| Citation | DRINKWATER,NR: MILLER,EC: MILLER,JA: PITOT,HC:. (1976). HEPATOCARCINOGENICITY OF ESTRAGOLE(1-ALLYL-4-METHOXYBENZENE) AND 1'-HYDROXYESTRAGOLE IN THE MOUSE AND MUTAGENICITY OF 1'-ACETOXYESTRAGOLE IN BACTERIA.. 57() |
| Amount utilized | |
| Compound isolated | |
| Disease | SIGNIFICANT INCREASES IN THE INCIDENCE OF HEPATOCELLULAR CARCINOMAS IN MALE CD-1 MICE THAT RECEIVED THE COMPOUND BY SC INJECTION AT 1-22 DAYS OF AGE. ESTRAGOLE INDUCED HEPATOCELLULAR CARCINOMAS BY 15 MONTHS IN 23% AND 39% OF MICE THAT RECEIVEDTOTAL DOSES OF 4.4 AND 5.2 MICROMOLS,RESPECTIVELY, AND LIVED TO AN AGE OF 12 MONTHS OR MORE. ADDITIONAL DETAILS OF THE INCIDENCE OF MULTIPLE TUMORS AND OTHER PARAMETERS ARE PRESENTED IN THE PAPER. |
| Dose amount | 0.17 MICROMOLS |
| Number | 4 |
| Qualitative result | ACTIVE |
| Animal | MOUSE |
| Per unit | ANIMAL |
| Dose expression | DOSE |
| Gender | MALE |