Experiment 1024927

Details

PropertyValue
Pharmacology
Administration routeGASTRIC INTUBATION
OrganismPanax ginseng (ARALIACEAE)
CitationTANIZAWA,H: NUMANO,H: ODANI,T: TAKINO,Y: HAYASHI,T: ARICHI,S:. (1981). STUDY ON THE SAPONIN OF PANAX GINSENG C.A.MEYER. I. INHIBITORY EFFECT ON ADRENAL ATROPHY, THYMUS ATROPHY AND THE DECREASE OF SERUM K CONCENTRATION INDUCED BY CORTISONE ACETATE IN UNILATERAL ADRENALECTOMIZED RATS.. 101()
Amount utilized
Compound isolated
DiseaseDAILY DOSING FOR 7 DAYS PRODUCED ANTAGONISM TO THE SUPPRESSIVE ACTION OF CORTISONE ACETATE ON COMPENSATORY ADRENAL HYPERTROPHY AFTER UNILATERAL ADRENALECTOMY. DATA WERE SUPPORTED BY HISTOLOGICAL STUDIES. THE FRACTION WAS ALSO FOUND TO BE ANTAGONISTIC TO THE DECREASE OF THYMUS WEIGHT AND SERUM K+ CONCENTRATIONS INDUCED BY CORTISONE ACETATE IN THESE ANIMALS. THE SAME DOSE OF EXTRACT ALONE HAD NO EFFECT ON COMPENSATORY ADRENAL HYPERTROPHY, THYMUS WEIGHT AND SERUM K+ CONCENTRATION IN THESE ANIMALS. HISTOLOGICALLY, THE EXTRACT HAD NO EFFECT ON IMPROVEMENT OF FATTY METAMORPHOSIS INDUCED BY CORTISONE ACETATE IN THE LIVER OF TREATED ANIMALS. THESE EFFECTS, EXCEPT FOR THE EFFECT ON SERUM K+ CONCENTRATION, WERE APPROXIMATELY THE SAME AS THOSE OF GLYCYRRHIZIN, BUT DIFFERENT FROM THOSE OF SAIKOSAPONIN(FROM BUPLEURUM FALCATUM.).
Dose amount200.0 MG
Number2
Qualitative resultACTIVE
AnimalRAT
Per unitKG
Dose expressionDOSE
ExtractSAPONIN FRACTION