Experiment 1027225

Details

PropertyValue
Pharmacology
Administration routeIV
OrganismEmpty organism
CitationSPREMULLI,E: SCHULZ,JJ: SPECKHART,VJ: WAMPLER,GL:. (1980). PHASE II STUDY OF VM-26 IN ADULT MALIGNANCIES.. 64()
Amount utilized
Compound isolated
DiseaseA PHASE II STUDY IN 96 PATIENTS WITH A VARIETY OF MALIGNANCIES. TEN PATIENTS WERE EXCLUDED FROM THE ANALYSIS. RESPONSES WERE SEEN IN JEJUNAL ADENOCARCINOMA(1/1 PATIENT),COLORECTAL CARCINOMA(2/14),LYMPHOMA(1/4)AND SMALL CELL CARCINOMA OF THE LUNG(1/2). PARTIAL RESPONSES WERE RECORDED IN BREAST CARCINOMA(4/11),SQUAMOUS CELL CARCINOMA OF THE LUNG(1/2),MALIGNANT GLIOMA(2/10)AND OVARIAN CARCINOMA(1/2). THE TITLE COMPOUND WAS FOUND TO BE A DRUG WITH LOW ACTIVITY BUT HIGH ACCEPTABILITY IN THIS ADVANCED CANCER POPULATION. MARROW DEPRESSION WAS THE MAIN TOXIC EFFECT AND WAS EASILY MANAGED.
Dose amount100.0 MG
Number1
Qualitative resultACTIVE
AnimalHUMAN ADULT
Per unitSQ M BODY SURFACE
Dose expressionDOSE