Experiment 1030640
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Streptomyces alanosinicus (STREPTOMYCETACEAE) |
| Citation | DOSIK,GM: STEWART,D: VALDIVIESO,M: BURGESS,MA: BODEY,GP:. (1982). PHASE I STUDY OF L-ALANOSINE USING A DAILY X 3 SCHEDULE.. 66() |
| Amount utilized | |
| Compound isolated | |
| Disease | A PHASE I STUDY OF THE TITLE COMPOUND WAS CARRIED OUT IN 19 CANCER PATIENTS FOR 117 COURSES. DOSING WAS THREE DAYS A WEEK EVERY THREE WEEKS. DOSE-LIMITING TOXIC EFFECT WAS MUCOSITIS. VOMITING,INFREQUENT MYELOSUPPRESSION, FEVER,HEADACHE,MALAISE AND BLOOD PRESSURE CHANGES WERE DETECTED AT HIGHER DOSE LEVELS. NO ANTITUMOR ACTIVITY WAS SEEN. TOXICITY WITH THIS REGIMEN IS ACCEPTABLE. IT WAS RECOMMENDED THAT A PHASE II STUDY BE CARRIED OUT WITH DOSES OF 250 M/SQ M/DAY X 3 EVERY THREE WEEKS WHERE FEASIBLE. |
| Dose amount | 8-375 MG |
| Number | 2 |
| Qualitative result | INACTIVE |
| Animal | HUMAN ADULT |
| Per unit | SQ M BODY SURFACE |
| Dose expression | DOSE |
| Gender | GIVEN TO BOTH SEXES |