Experiment 1031205

Compounds isolated

Details

PropertyValue
Pharmacology
Administration routeGASTRIC INTUBATION
OrganismSymphytum officinale (BORAGINACEAE)
CitationBRAUCHLI,J: LUTHY,J: ZWIFEL,U: SCHLATTER,C:. (1982). PYRROLIZIDINE ALKALOIDS FROM SYMPHYTUM OFFICINALE L. AND THEIR PRECUTANEOUS ABSORPTION IN RATS.. 38()
Amount utilized
Compound isolated
DiseaseORAL ADMINISTRATION OF AN ETHANOLIC EXTRACT OF THE ROOTS (CONTAINING THE N-OXIDES OF LYCOPSAMINE, SYMPHYTINE, INTERMEDINE, 7-ACETYLLYCOPSAMINE AND 7-ACETYLINTERMEDINE) SHOWED ABSORPTION AND EXCRETION OF THE ALKALOIDS AS N-OXIDES. ABOUT 20 TIMES GREATER ABSORPTION OF THE ALKALOIDS WAS SHOWN THAN BY THE DERMAL ROUTE, AS EVIDENCED BY EXAMINATION OF URINE.
Dose amount194.0 MG
Number2
Qualitative result.
AnimalRAT
Per unitKG
Dose expressionDOSE
ExtractETOH(95%)EXT