Experiment 1031206
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | EXTERNAL |
| Organism | Symphytum officinale (BORAGINACEAE) |
| Citation | BRAUCHLI,J: LUTHY,J: ZWIFEL,U: SCHLATTER,C:. (1982). PYRROLIZIDINE ALKALOIDS FROM SYMPHYTUM OFFICINALE L. AND THEIR PRECUTANEOUS ABSORPTION IN RATS.. 38() |
| Amount utilized | |
| Compound isolated | |
| Disease | THE PERCUTANEOUS ABSORPTION OF ALKALOIDS(LYCOPSAMINE,INTERMEDINE,SYMPHYTINE,7-ACETYLINTERMEDINE AND 7-ACETYLLYCOPSAMINE,AS N-OXIDES) WAS STUDIED IN RATS. THE DOSE APPLIED CORRESPONDED TO 194 MG OF ALKALOID-N-OXIDES/KG. THE EXCRETION OF DERMALLY ABSORBED N-OXIDES IN THE URINE DURING TWO DAYS WAS IN THE RANGE OF 0.1 TO 0.4% OF THE DOSE APPLIED. THE DERMALLY ABSORBED N-OXIDES ARE NOT, OR ONLY TO A SMALL EXTENT,CONVERTED TO THE FREE BASE ALKALOIDS IN THE RAT. |
| Dose amount | 194.0 MG |
| Number | 3 |
| Qualitative result | . |
| Animal | RAT |
| Per unit | KG |
| Dose expression | CONC USED |
| Extract | ETOH(95%)EXT |