Experiment 1031212
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Organism | Empty organism |
| Citation | OGURO,M: NAGANO,H:. (1982). THE INHIBITORY MODE OF APHIDICOLIN ON DNA SYNTHESIS IN NACL-TREATED HELA CELL NUCLEI.. 91() |
| Amount utilized | |
| Compound isolated | |
| Disease | ISOLATED HELA CELL NUCLEI WERE TREATED WITH NACL AT VARIOUS CONCENTRATIONS AND INHIBITION BY APHIDICOLIN OF DNA SYNTHESIS IN THE TREATED NUCLEI WAS STUDIED. THE INHIBITION WAS EITHER NON-COMPETITIVE OR OF THE MIXED TYPE WITH RESPECT TO EACH D-NTP WHEN THE NUCLEI WERE TREATED WITH NACL AT CONCENTRATIONS LOWER THAN 0.08M. HOWEVER, APHIDICOLIN WAS A COMPETITIVE INHIBITOR WITH RESPECT TO D-CIP AND A NON-COMPETITIVE OR MIXED TYPE INHIBITOR WITH RESPECT TO THE OTHER 3 D-NTP'S WHEN THEY WERE TREATED WITH NACL AT CONCENTRATIONS HIGHER THAN O.1M. THESE RESULTS SUGGEST THE PRESENCE OF NUCLEAR FACTOR(S) RESPONSIBLE FOR THE CHANGES IN THE INHIBITORY MODE OF APHIDICOLIN ON ENDOCENOUS NUCLEAR DNA SYNTHESIS. |
| Dose amount | 0.08 MOL |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | CELL CULTURE |
| Dose expression | CONC USED |