| Disease | BLOOD RADIOACTIVITY LEVEL DECREASED RAPIDLY AFTER INJECTION INTO TWO BIOLOGICAL PHASES: THE DISTRIBUTION PHASE WITH A HALF LIFE OF 2.1 MINUTES AND THE ELIMINATION PHASE, WITH A HALF LIFE OF 53.7 MINUTES.
THE SHAPE OF THE BLOOD RADIOACTIVITY LEVEL VS. TIME CURVE MAY BE FITTED TO A TWO-COMPARTMENT OPEN MODEL.
FIFTEEN MINUTES AFTER INJECTION TO NORMAL RATS, THE HIGHEST LEVEL OF RADIOACTIVITY WAS PRESENT IN THE BONE MARROW, WHILE APPRECIABLE RADIOACTIVITY WAS PRESENT IN THE KIDNEYS,LIVER,LUNGS,SPLEEN,HEART AND GASTROINTESTINAL TRACT.
RADIOACTIVITY IN THE MUSCLES, WHOLE BLOOD AND BRAIN WAS LOW.
TWO HOURS AFTER INJECTION, THE RADIOACTIVITY LEVEL IN VARIOUS TISSUES DECREASED RAPIDLY, BUT THAT OF THE GASTROINTESTINAL TRACT DECREASED MORE SLOWLY. TWENTY-FOUR HOURS AFTER INJECTION,ONLY VERY LOW LEVELS OF RADIOACTIVITY WERE FOUND IN ALL TISSUES.
IN TUMOR-BEARING MICE,A SIMILAR DISTRIBUTION PATTERN WAS OBSERVED.
TWENTY-FOUR HOURS AFTER ADMINISTRATION TO NORMAL RATS,THE TOTAL URINARY EXCRETION OF RADIOACTIVITY WAS FOUND TO BE ABOUT 42.2% WHILE ABOUT 6.3% WAS PRESENT IN THE FECES.
IT WAS SHOWN THAT ONLY ABOUT 15.9% OF THE RADIOACTIVITY WAS EXCRETED AS UNCHANGED DRUG WITHIN 24 HOURS.
BILIARY EXCRETION WAS AN IMPORTANT ROUTE OF EXCRETION. NORMAL RATS EXCRETED 57.7% OF ADMINISTERED RADIOACTIVITY IN THE BILE IN 48 HOURS WHILE ONLY 20.2% WAS IN UNCHANGED FORM.
IT WAS SHOWN THAT HOMOHARRINGTONINE IS DISTRIBUTED WIDELY IN THE BODY AND ELIMINATED AT A FAIRLY RAPID RATE, THUS ACCUMULATION IN THE BODY IS UNLIKELY. |