Experiment 1031660
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | EXTERNAL |
| Organism | Empty organism |
| Citation | NELSON,KG: STEPHENSON,KB: SLAGA,TJ:. (1982). PROTEIN MODIFICATIONS INDUCED IN MOUSE EPIDERMIS BY POTENT AND WEAK TUMOR-PROMOTING HYPERPLASIOGENIC AGENTS.. 42() |
| Amount utilized | |
| Compound isolated | |
| Disease | THE TITLE COMPOUND CAUSED MANY CHANGES IN THE EPIDERMAL PROTEIN PROFILES ESPECIALLY RELATED TO KERATINS WHICH ARE THE MAJOR DIFFERENTIATION PRODUCT OF THE EPIDERMIS. THE KERATIN MODIFICATION PROGRESSES WITH TIME AFTER TPA TREATMENT, RESULTING IN A KERATIN PATTERN THAT RESEMBLES THAT OF NEWBORN MOUSE EPIDERMIS. PROTEIN ALTERATIONS ARE OBSERVED NOT ONLY EARLY DURING TREATMENT WITH THE TITLE COMPOUND INDUCTION OF HYPERPLASIA AND INFLAMMATION AT 48 AND 72 HOURS,BUT ALSO IN 1- + 2-WEEK SAMPLES IN WHICH THE MORRPHOLOGY OF THE EPIDERMIS HAS RETURNED TO NORMAL. |
| Dose amount | 5.0 MCG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | MOUSE |
| Per unit | ANIMAL |
| Dose expression | CONC USED |
| Gender | FEMALE |