Experiment 1031776
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | GASTRIC INTUBATION |
| Organism | Empty organism |
| Citation | GOSALVEZ,M:. (1983). CARCINOGENESIS WITH THE INSECTICIDE ROTENONE.. 32(8) |
| Amount utilized | |
| Compound isolated | |
| Disease | A REVIEW(1983) ON THE CARCINOGENESIS POTENTIAL OF THE TITLE COMPOUND WITH 32 REFERENCES. ROTENONE IS AN INSECTICIDE WHICH HAS BEEN USED EXTENSIVELY FOR A LONG TIME AND IS NOW CURRENTLY USED WIDELY IN THE U.S.A. AND OTHER INDUSTRIALIZED COUNTRIES. THIS REVIEW COVERS PUBLISHED AND UNPUBLISHED REPORTS DEALING WITH THE CAPACITY FOR THE TITLE COMPOUND TO INDUCE NEOPLASTIC,PARANEOPLASTIC AND PRENEOPLASTIC LESIONS IN THE RAT. IT IS STRONGLY SUGGESTED THAT ROTENONE IS CARCINOGENIC TO THE RAT AT DOSES FROM 2-25 PPM CONTINUOUSLY IN FOOD,OR FROM 0.8-25.0 MG/KG ORALLY FOR 1-4 MOS.,WHEN RATS RECEIVE DEFICIENT DIETS,ESPECIALLY THOSE DEFICIENT IN RIBOFLAVIN. ROTENONE CARCINOGENICITY, AMONG OTHER THINGS, SEEMS TO EXHIBIT A PECULIAR DOSE-RESPONSE PATTERN,WHICH COULD BE EXPLAINED BY ITS POSSIBLE HORMONAL MECHANISM OF ACTION. FURTHER STUDIES TO ASSESS DEFINITIVELY THE ROLE OF ROTENONE AS A POSSIBLE ENVIRONMENTAL CARCINOGEN ARE PROPOSED AS BEING HIGHLY NECESSARY. |
| Dose amount | 1-25 MG |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Per unit | KG |
| Dose expression | DOSE |