Experiment 1036200
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | INTRALUMINAL |
| Organism | Empty organism |
| Citation | SACK,RB: FROEHLICH,JL:. (1982). BERBERINE INHIBITS INTESTINAL SECRETORY RESPONSE OF VIBRIO CHOLERAE AND ESCHERICHIA COLI ENTEROTOXINS.. 35() |
| Amount utilized | |
| Compound isolated | |
| Disease | THE TITLE COMPOUND INHIBITED BY CA.70% THE SECRETORY RESPONSES OF THE HEAT LABILE ENTEROTOXINS OF VIBRIO CHOLERA AND ESCHERICHIA COLI IN THE RABBIT LIGATED INTESTINAL LOOP MODEL. THE DRUG WAS EFFECTIVE WHEN GIVEN EITHER BEFORE OR AFTER ENTEROTOXIN BINDING AND WHEN GIVEN EITHER INTRALUMINALLY OR PARENTERALLY. IT DID NOT INHIBIT THE STIMULATION OF ADENYLATE CYCLASE BY CHOLERA ENTEROTOXIN AND CAUSED NO DAMAGE TO THE INTESTINAL MUCOSA. |
| Dose amount | 10.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | RABBIT |
| Per unit | ANIMAL |
| Dose expression | DOSE |