Experiment 1036201

Compounds isolated

Details

PropertyValue
Pharmacology
Administration routeSC
OrganismEmpty organism
CitationSACK,RB: FROEHLICH,JL:. (1982). BERBERINE INHIBITS INTESTINAL SECRETORY RESPONSE OF VIBRIO CHOLERAE AND ESCHERICHIA COLI ENTEROTOXINS.. 35()
Amount utilized
Compound isolated
DiseaseTHE TITLE COMPOUND INHIBITED BY CA.70% THE SECRETORY RESPONSES OF THE HEAT LABILE ENTEROTOXINS OF VIBRIO CHOLERA AND ESCHERICHIA COLI IN THE RABBIT LIGATED INTESTINAL LOOP MODEL. THE DRUG WAS EFFECTIVE WHEN GIVEN EITHER BEFORE OR AFTER ENTEROTOXIN BINDING AND WHEN GIVEN EITHER INTRALUMINALLY OR PARENTERALLY. IT DID NOT INHIBIT THE STIMULATION OF ADENYLATE CYCLASE BY CHOLERA ENTEROTOXIN AND CAUSED NO DAMAGE TO THE INTESTINAL MUCOSA.
Dose amount10.0 MG
Number2
Qualitative resultACTIVE
AnimalRABBIT
Per unitANIMAL
Dose expressionDOSE