Experiment 1037120
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | ARNOLD,AM: WHITEHOUSE,JMA:. (1981). ETOPOSIDE: A NEW ANTI-CANCER AGENT.. 1981(II) |
| Amount utilized | |
| Compound isolated | |
| Disease | A REVIEW(1981) WITH 30 REFERENCES ON THE VALUE OF THE TITLE COMPOUND IN TREATING HUMAN CANCER. THE COMPOUND APPEARS TO ACT BY PRODUCING SINGLE-STRAND BREAKS IN DNA AND DOES NOT INHIBIT MICROTUBULE ASSEMBLY. THE DRUG APPEARS TO BE SCHEDULE-DEPENDENT AND IS BEST GIVEN OVER A PERIOD OF 3-5 DAYS REPEATED AT INTERVALS OF 2-3 WEEKS. TOXICITY IS PREDICTABLE AND REVERSIBLE AND NO LONG-TERM TOXICITY HAS BEEN REPORTED. THE DRUG SHOWS ACTIVITY IN LUNG CANCER, TESTICULAR CARCINOMA, CHORIOCARCINOMA AND IN SOME LEUKEMIAS AND LYMPHOMAS. IT CAN BE ADMINISTERED ORALLY AS WELL AS PARENTERALLY. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |