Experiment 1039454

Compounds isolated

Details

PropertyValue
Pharmacology
OrganismEmpty organism
CitationHOWELL,SL: HII,CS: SHAIKH,S: TYHURST,M:. (1982). EFFECTS OF TAXOL AND NOCODAZOLE ON INSULIN SECRETION FROM ISOLATED RAT ISLETS OF LANGERHANS.. 2()
Amount utilized
Compound isolated
DiseaseTAXOL IS A PROMOTER OF MICROTUBULE POLYMERIZATION. IN THIS STUDY,TAXOL WAS SHOWN TO INHIBIT GLUCOSE-STIMULATED INSULIN SECRETION FROM ISOLATED RAT ISLETS OF LANGERHANS. THESE FINDINGS SUGGEST THAT THE DYNAMIC REGULATION OF MICROTUBLE POLYMERIZATION-DEPOLYMERIZATION IN PANCREATIC BETA CELLS MAY BE IMPORTANT FOR INSULIN SECRETION VIA THE MICROTUBULE-MICROFILAMENTOUS SYSTEM.
Dose amount10.0 MICROMOLS
Number1
Qualitative resultACTIVE
AnimalRAT
Dose expressionCONC USED