Experiment 1039823
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Organism | Empty organism |
| Citation | ROUOT,B: QUENNEDEY,MC: SCHWARTZ,J:. (1982). CHARACTERISTICS OF THE (3H)-YOHIMBINE BINDING ON RAT BRAIN ALPHA-2-ADRENOCEPTORS.. 321() |
| Amount utilized | |
| Compound isolated | |
| Disease | THE LABELLING OF RAT CEREBRAL CORTEX ALPHA-2-ADRENOCEPTORS WITH TRITIATED YOHIMBINE WAS INVESTIGATED. AT 25 C,BINDING EQUILIBRIUM WAS REACHED IN ABOUT 10 MINUTES AND DISSOCIATION OCCURRED WITH A HALF TIME OF ABOUT 1 MINUTE. SATURATION EXPERIMENTS GAVE AN EQUILIBRIUM F-D VALUE OF 10.13 NMOL AND A MAXIMUM NO. OF SITES OF 254 FMOL/MG PROTEIN. THE TRITIATED YOHIMBINE BINDING SITES EXHIBITED ALPHA-2-ADRENERGIC RECEPTOR SPECIFICITY, THE ORDER OF POTENCY FOR THE ANTAGONISTS WAS RAUWOLSCINE GREATER THAN YOHIMBINE GREATER THAN PRAZOSIN GREATER THAN CORYNANTHINE. |
| Dose amount | 0.1 MILLIMOLS |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Dose expression | CONC USED |
| Gender | MALE |