Experiment 1040968
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Organism | Empty organism |
| Citation | ANAND-SRIVASTAVA,MB: CNATIN,M:. (1983). REQUIREMENT OF GUANIME-NUCLEOTIDE REGULATORY PROTEIN AND PHOSPHOLIPIDS IN THE FORSKOLIN ACTIVATION OF MYOCARDIAL ADENYLATE CYCLASE.. 25(3) |
| Amount utilized | |
| Compound isolated | |
| Disease | THE INVOLVEMENT OF GUANINE NUCLEOTIDE REGULATORY PROTEIN AND PHOSPHOLIPIDS FOR FORSKOLIN ACTIVATION OF ADENYLATE CYCLASE WAS STUDIED IN HEART SARCOLEMMA BY USING PHOSPHOLIPASES,LUBROL-PX AND GTP-SEPHAROSE AFFINITY CHROMATOGRAPHY. LUBROL-PX TREATMENT OF THE MYOCARDIAL SARCOLEMMA INHIBITED F- AND FORSKOLIN-STIMULATED ADENYLATE CYCLASE ACTIVITIES. SIMILIAR INHIBITION OF F-,FORSKOLIN AND GUANINE NUCLEOTIDE RESPONSIVE ADENYLATE CYCLASE ACTIVITIES WAS ALSO OBSERVED IN LUBROL-PX SOLUBILIZED MEMBRANES. WHEN GUANINE NUCLEOTIDE REGULATORY PROTEIN WAS REMOVED FROM THE 100,000 X G SUPERNATANT FRACTION BY GTP-SEPHAROSE AFFINITY CHROMATOGRAPHY,THE STIMULATION WAS ALMOST COMPLETELY ABOLISHED. PHOSPHOLIPASE A-2 AND C TREATMENTS OF THE MYCOCARDIAL SARCOLEMMA RESULTED IN A SIGNIFICANT DECREASE IN F- AND FORSKOLIN-STIMULATED ADENYLATE CYCLASE ACTIVITIES. THESE DATA SUGGEST THAT GUANINE NUCLEOTIDE REGULATORY PROTEIN AND PHOSPHOLIPIDS MAY BE REQUIRED FOR F- AND FORSKOLIN ACTIVATION OF ADENYLATE CYCLASE IN HEART SARCOLEMMA. |
| Number | 1 |
| Qualitative result | ACTIVE |
| Dose expression | CONC USED |