Experiment 1042968
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Empty organism |
| Citation | NEIDHART,JA: YOUNG,DC: DEROCHER,D: METZ,EN:. (1983). PHASE I TRIAL OF HOMOHARRINGTONINE.. 67(9) |
| Amount utilized | |
| Compound isolated | |
| Disease | THIS WAS A PHASE I STUDY USING A SINGLE INFUSION OF HOMOHARRINGTONINE OVER 90 MINUTES GIVEN EVERY 21 DAYS. DOSE-RELATED AND LIFE-THREATENING HYPOTENSION, WITHOUT SIGNIFICANT MYELOSUPPRESION WAS THE DOSE-LIMITING TOXIC EFFECT. THE MECHANISM OF HYPOTENSION IS NOT UNDERSTOOD BUT IT IS NOT RELATED TO CARDIAC ARRHYTHMIAS. MYELOSUPPRESSION WAS NOT SEEN REGULARLY. ON THE BASIS OF THIS STUDY HOMOHARRINGTONINE WAS NOT RECOMMENDED FOR PHASE II STUDIES. |
| Dose amount | 1.3-6 MG |
| Number | 1 |
| Qualitative result | INACTIVE |
| Animal | HUMAN ADULT |
| Per unit | SQ M BODY SURFACE |
| Dose expression | DOSE |