Experiment 1043155

Details

PropertyValue
Pharmacology
Administration routeIV INFUSION
OrganismEmpty organism
CitationFERRETTI,PG: BIA,A: BUFALINO,L: CAVRINI,P: CUCINOTTA,D:. (1982). EFFECTS OF ACUTE AND CHRONIC TREATMENT WITH (-)EBURNAMONINE ON THE TISSUE SUPPLY OF OXYGEN.. 3()
Amount utilized
Compound isolated
DiseaseA DOUBLE-BLIND STUDY ON 20 ELDERLY VOLUNTEER SUBJECTS(HALF WERE CONTROLS). THERE WAS A SIGNIFICANT INCREASE IN BLOOD LEVELS OF 2,3-DIPHOSPHOGLYCERATE AND A BENEFICIAL MODIFICATION OF THE OXYHB DISSOCIATION CURVE(P50) AFTER DRUG TREATMENT, BOTH INDEXES OF OXYGEN TRANSPORT AND DELIVERY TO TISSUES. EFFECT OF THE DRUG WAS MORE MARKED BUT MORE FLEETING AFTER ACUTE ADMINISTRATION, LESS INTENSE BUT MORE LASTING AFTER CHRONIC ADMINISTRATION. THE LATTER MODE OF TREATMENT IS OF INTEREST IN VIEW OF THERAPEUTIC EFFECTS ON SENILE CHRONIC CEREBRAL INSUFFICIENCY.
Dose amount100.0 MG
Number1
Qualitative resultACTIVE
AnimalHUMAN ADULT
Per unitPERSON
Dose expressionDOSE