Experiment 1046535

Details

PropertyValue
Pharmacology
Administration routeORAL
OrganismAllium sativum (LILIACEAE)
CitationCAPORASO,N: SMITH,SM: ENG,RHK:. (1983). ANTIFUNGAL ACTIVITY IN HUMAN URINE AND SERUM AFTER INGESTION OF GARLIC (ALLIUM SATIVUM).. 23(5)
Amount utilized
Compound isolated
DiseaseA FRESH EXTRACT OF GARLIC WAS ADMINISTERED ORALLY TO HUMAN VOLUNTEERS. AT INTERVALS,SERUM AND URINE WERE COLLECTED AND ASSAYED FOR ANTIFUNGAL ACTIVITY. THE MAXIMUM TOLERABLE DOSE OF THE EXTRACT WAS DETERMINED TO BE 25 ML. LARGER AMOUNTS CAUSED SEVERE BURNING SENSATIONS IN THE STOMACH & ESOPHAGUS AND VOMITING. AFTER ORAL INGESTION OF THE EXTRACT, ANTICANDIDAL AND ANTICRYPTOCOCCAL ACTIVITIES WERE DETECTED IN UNDILUTED SERUM 0.5 AND 1 HOUR AFTER INGESTION. NO ACTIVITY WAS FOUND AT COMPARABLE TIMES IN THE URINE. IT WAS CONCLUDED THAT ORAL GARLIC IS OF LIMITED VALUE IN THE THERAPY OF HUMAN FUNGAL INFECTIONS.
Dose amount10-25 ML
Number16
Qualitative resultWEAK ACTIVITY
AnimalHUMAN ADULT
Per unitPERSON
Dose expressionDOSE
ExtractH2O EXT