Experiment 1048311
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Organism | Empty organism |
| Citation | FUKUDA,M: OHASHI,M:. (1983). APHIDICOLIN INHIBITS CELL GROWTH BY ACCUMULATION OF G2 CELLS.. 7(8) |
| Amount utilized | |
| Compound isolated | |
| Disease | IN ORDER TO CLARIFY IN VIVO TARGETS OF THE TITLE COMPOUND,THE CELL CYCLE PHASE AT WHICH NORMAL HUMAN DIPLOID CELLS WERE ACCUMULATED WITH THIS DRUG WERE EXAMINED. MORE THAN 80% OF THE CELLS MOVED THROUGH S PHASE AND ACCUMULATED IN G2 WHEN APHIDICOLIN WAS PRESENT. IT COMPLETELY INHIBITED CELL GROWTH BUT DID NOT CAUSE CELL DEATH. AT THIS DOSE, CELL DETACHMENT OCCURRED THROUGH THE FIRST ENTRY OF THE CELLS INTO EARLY S PHASE. APPARENTLY, IN VIVO EFFECTS OF APHIDICOLIN ARE MUCH MORE COMPLICATED THAN SIMPLE INHIBITION OF DNA SYNTHESIS. |
| Dose amount | 0.4 MCG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | CELL CULTURE |
| Per unit | ML |
| Dose expression | CONC USED |