Experiment 1048440
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Catha edulis (CELASTRACEAE) |
| Citation | KALIX,P:. (1984). AMPHETAMINE PSYCHOSES DUE TO KHAT LEAVES.. 1984() |
| Amount utilized | |
| Compound isolated | |
| Disease | A BRIEF NOTE INDICATING THAT "THE CHEWING OF KHAT CAUSES A CERTAIN DEGREE OF EUPHORIA AND HYPERACTIVITY ACCOMPANIED BY SYMPATHOMIMETIC SIDE EFFECTS. EVEN THOUGH THE HABIT WAS DESCRIBED MORE THAN SEVEN CENTURIES AGO,IT HAS REMAINED ENDEMIC TO THE AREAS OF CULTIVATION OF THE PLANT. FURTHER: "HOWEVER,THE INCREASING USE OF KHAT IN THESE AREAS AND THE CONSEQUENT SOCIOECONOMIC COMPLICATIONS AND IMPACT ON PUBLIC HEALTH HAVE PROMPTED INTERNATIONAL BODIES,INCLUDING THE WHO,TO DISCUSS THE PROBLEM." KHAT LEAVES CONTAIN A POTENT PHENYLALKYLAMINE ALKALOID CALLED (-)-CATHINONE. THIS COMPOUND HAS PHARMACOLOGICAL PROPERTIES ANALOGOUS TO THOSE OF (+)-AMPHETAMINE AND IS OF SIMILAR POTENCY. FURTHERMORE,(-)-CATHINONE ACTS BY INDUCING RELEASE AT PHYSIOLOGICAL CATECHOLAMINE STORAGE CENTERS. ONLY FRESH LEAVES ARE ACTIVE. CASES OF KHAT-INDUCED PSYCHOSIS ARE INFREQUENT SINCE KHAT USE IS SELF-LIMITING,THE MATERIAL BEING SO BULKY. IN THE U.S.A.,A CASE OF A NORTH AFRICAN STUDENT IS DESCRIBED,WHO GREW THE PLANT IN HIS FLAT,SUGGESTING THAT OTHER CASES MIGHT OCCUR IN NORTH AMERICA AND EUROPE. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Extract | LEAVES |