Experiment 1048937

Worktypes

PHARMACOLOGY OF COMPOUND - IN VIVOSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODE

Compounds isolated

LAPACHOLPHTHIOCOLNAPHTHOQUINONE,1-4: 2-METHOXY:NAPHTHOQUINONE,1-4: 2-HYDROXY:

Alerts

DATA INCOMPLETE - DERIVED FROM AN ABSTRACT.

Details

PropertyValue
Pharmacology
PROTEIN SYNTHESIS STIMULATION
Administration routeIP
OrganismEmpty organism
CitationMACK,DO: CURTIS,TA: JOHNSON,BC:. (1980). STIMULATION OF VITAMIN K-1 PROTEIN CARBOXYLATION BY SEVERAL 1,4-NAPHTHOQUINONES.. ()
Amount utilized
Compound isolated
DiseaseTHE TITLE COMPOUND STIMULATED PROTEIN CARBOXYLATION IN LIVER MICROSOMAL PREPARATIONS FROM VITAMIN K-DEFICIENT RATS WHEN IT WAS INITIATED BY VITAMIN K QUINONE PLUS NADH, BUT NOT WHEN IT WAS INITIATED BY VITAMIN K-1 HYDROQUINONE. THE STIMULATION WAS PRIMARILY DUE TO AN INCREASE IN THE INITIAL RATE OF CARBOXYLATION. INCREASING THE TEMPERATURE FROM O TO 20 C RESULTED IN AN INCREASE IN CARBOXYLATION, WITH A DECREASE OBSERVED AT 37 C.
Number1
Qualitative resultACTIVE
AnimalRAT
Dose expressionDOSE