Experiment 1055586

Details

PropertyValue
Pharmacology
Administration routeIV
OrganismEmpty organism
CitationTAYLOR,S: BELT,RJ: HAAS,CD: HOOGSTRATEN,B:. (1983). PHASE I TRIAL OF INDICINE-N-OXIDE ON TWO DOSE SCHEDULES.. 51(11)
Amount utilized
Compound isolated
DiseaseA PHASE I CLINICAL STUDY IN 26 PATIENTS USING AN INTERMITTENT SCHEDULE UTILIZING SINGLE DOSES REPEATED EVERY 3-4 WEEKS. MYELOSUPPRESSION IS PREDICTABLE AND REVERSIBLE. IT IS MORE SEVERE IN PATIENTS WITH HEAVY PRIOR TREATMENT. THROMBOCYTOPENIA WAS MORE SEVERE THAN LEUKOPENIA. PARTIAL RESPONSES WERE SEEN IN 4 PATIENTS, ONE WITH A MUCOEPIDERMOID CARCINOMA OF THE SALIVARY GLAND AND 3 WITH ADENOCARCINOMA OF THE COLON. PHASE II STUDIES ARE PLANNED.
Dose amount5-10 GM
Number2
Qualitative resultACTIVE
AnimalHUMAN ADULT
Per unitPERSON
Dose expressionDOSE