Experiment 1055847
Compounds isolated
Alerts
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | GASTRIC INTUBATION |
| Organism | Empty organism |
| Citation | MC VIE,JG: BOKKEL HUININK,WW: SIMONETTI,G: DUBBELMAN,R:. (1984). PHASE I TRIAL OF N-METHYLFORMAMIDE.. 68(4) |
| Amount utilized | |
| Compound isolated | |
| Disease | A PHASE I TRIAL. ESCALATING DOSES GIVEN IN TWO TO THREE WEEK CYCLES AND ADMINISTERED ORALLY OR BY IV. ORAL ABSORPTION WAS GOOD AND IS PREFERRED. DOSES RANGED FROM 300 MG/M2 X5 TO 1200 MG/M2 X5. DOSE LIMITING TOXICITY IS HYPEBILIRUBINEMIA. INTERACTION WITH ALCHOHOL WAS ALSO SEEN. RISES IN SGOT AND SGPT WERE SEEN. OF 19 PATIENTS 2 HAD PARTIAL REMISSIONS (LYMPH NODE METASTASIS FROM PROSTATE CANCER AND UTERINE CERVIX CARCINOMA), 2 HAD MINOR RESPONSES(OVARIAN CANCER AND HYPERNEPHROMA). TWO PATIENTS HAD STABLE DISEASE STATES. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | . |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |