Experiment 1056860
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Organism | Empty organism |
| Citation | WENKE,G: HOFFMANN,D:. (1983). A STUDY OF BETEL QUID CARCINOGENESIS. 1. ON THE IN VITRO N-NITROSATION OF ARECOLINE.. 4(2) |
| Amount utilized | |
| Compound isolated | |
| Disease | THE STUDY IS BASED ON THE HYPOTHESIS THAT ARECOLINE, THE MAJOR ALKALOID IN BETEL NUT, IS METABOLIZED TO FROM CARCINOGENIC N-NITROSAMINES DURING CHEWING. THESE TESTS DEMONSTRATE THAT N-NITROSATION OF ARECOLINE LEADS TO N-NITROSOGUVACOLINE (NG), 3-(METHYLNITROSAMINO) PROPIONITRILE (MNPN) AND 3-(METHYLNITROSOAMINO) PROPIONALDEHYDE. RESULTS FROM ANOTHER STUDY SHOW THAT NG IS PROBABLY NOT CARCINOGENIC, HOWEVER MNPN MAY BE A STRONG ANIMAL CARCINOGEN BASED ON BIOASSAYS ITS LOWER HOMOLOGUE. THE CONDITIONS PREVAILING IN THE ORAL CAVITY OF BETEL QUID CHEWERS ARE LIKELY TO FAVOR THE FORMATION OF THESE THREE NITROSAMINES. |
| Number | 1 |
| Qualitative result | ACTIVE |
| Dose expression | CONC USED |