Experiment 1072278
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Empty organism |
| Citation | BEDIKIAN,AY: VALDIVIESO,M: BODEY,GP: MURPHY,WK: FREIREICH,EJ:. (1979). INITIAL CLINICAL STUDIES WITH BRUCEANTIN.. 63() |
| Amount utilized | |
| Compound isolated | |
| Disease | PHASE I CLINICAL STUDY IN 66 PATIENTS WITH VARIOUS TYPES OF ADVANCED SOLID TUMORS-DOSING DAILY X 5 DAYS HYPOTENSION WAS THE MAJOR DOSE-LIMITING TOXIC EFFECT:IT WAS DELAYED,CUMULATIVE AND OCCURRED MORE OFTEN IN PATIENTS WITH ABNORMAL PRETREATMENT LIVER FUNCTION. NAUSEA,VOMITING AND FEVER WERE COMMON AT HIGHER DOSES,AND DIARRHEA,STOMATITIS,ALOPECIA,PARESTHESIA AND RASH WERE OBSERVED IN SOME PATIENTS HEMATOLOGIC TOXICITY WAS MODERATE AT HIGH DOSES AND WAS MANIFESTED MAINLY AS THROMBOCYTOPENIA |
| Dose amount | 3.0 MG |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | SQ M BODY SURFACE |
| Dose expression | DOSE |
| Gender | GIVEN TO BOTH SEXES |