Experiment 1072286
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Maytenus buchananii (CELASTRACEAE) |
| Citation | CHAHINIAN,AP: NOGEIRE,C: OHNUMA,T: GREENBERG,ML: SIVAK,M: JAFFREY,FH: HOLLAND,JF:. (1979). PHASE I STUDY OF WEEKLY MAYTANSINE GIVERN BY IV BOLUS OR 24 HOUR INFUSION.. 63() |
| Amount utilized | |
| Compound isolated | |
| Disease | A PHASE I CLINICAL TRIAL IN 71 PATIENTS WITH LEUKEMIA, LYMPHOMA OR CARCINOMA BY WEEKLY IV BOLUS OR 24-HOUR INFUSION THE MOST PROMINENT TOXICITY WAS NEUROLOGICAL,CONSISTING OF A VARIABLE COMBINATION OF A PERIPHERAL,PREDOMINANTLY SENSORY POLYNEUROPATHY AND A GENERALIZED PSYCHOMOTOR DEPRESSION OF APPAREN GASTROINTESTINAL TOXICITY MANIFESTED BY NAUSEA,VOMITINT,DIARRHEA AND ABDOMINAL CRAMPS,WAS FREQUENT AT DOSES GREATER THAN 1.1 MG/SQ M/WEEK A FEW PATIENTS EXPERIENCED SEVERE HEPATOTOXIC EFFECTS AND MYELOSUPPRESSION. ONE PATIENT EACH WITH CARCINOMA OF THE LUNG,THYMOMA AND DIFFUSE HISTIOCYTIC LYMPHOMA RESPONDED WITH GREATER THAN 50% REGRESSION OF TUMOR |
| Dose amount | 1.0 MG |
| Number | 1 |
| Qualitative result | EQUIVOCAL |
| Animal | HUMAN ADULT |
| Per unit | SQ M BODY SURFACE |
| Dose expression | DOSE |
| Gender | GIVEN TO BOTH SEXES |