Experiment 1072289
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Maytenus buchananii (CELASTRACEAE) |
| Citation | CREAGEN,ET: FLEMING,TR: EDMONSON,JH: INGLE,JN:. (1979). PHASE II EVALUATION OF MAYTANSINE IN PATIENTS WITH ADVANCED HEAD AND NECK CANCER.. 63() |
| Amount utilized | |
| Compound isolated | |
| Disease | A PHASE II STUDY 31 PATIENTS WITH MEASURABLE OR EVALUABLE ADVANCED HEAD AND NECK CANCER(MEDIAN AGE = 62) DOSING WAS FOR 3 CONSECUTIVE DAYS WITH THE FIRST RETREATMENT 3 WEEKS LATER AND SUBSEQUENT RETREATMENTS AT 4-WEEK INTERVALS TOXICITY WAS MAINLY GASTROINTESTINAL:MODERATE TO SEVERE NAUSEA AND VOMITING OCCURRED IN 6/31 PATIENTS DIARRHEA WAS MODERATE TO SEVERE IN 5/31 PATIENTS. ONLY 1/31(3%),PATIENTS HAD GREATER THAN A 50% OBJECTIVE RESPONSE CONCLUSION:MAYTANSINE WAS NOT RECOMMENDED FOR FURTHER STUDY IN HEAD AND NECK CANCER |
| Dose amount | 0.6 MG |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | SQ M BODY SURFACE |
| Dose expression | DOSE |
| Gender | GIVEN TO BOTH SEXES |