Experiment 1072291
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Catharanthus roseus (APOCYNACEAE) |
| Citation | KELSEN,DP: BAINS,M: CVITKOVIC,E: GOLBEY,R:. (1979). VINDESINE IN THE TREATMENT OF ESOPHAGEAL CARCINOMA:A PHASE II STUDY.. 63() |
| Amount utilized | |
| Compound isolated | |
| Disease | A PHASE II CLINICAL STUDY IN 26 PATIENTS WITH SQUAMOUS CELL CARCINOMA OF THE ESOPHAGUS DOSING WAS ONCE WEEKLY FOR 7 DOSES AND THEN BIWEEKLY UNTIL DISEASE PROGRESSION,OR UNTIL TOXICITY BECAME SEVERE ENOUGH TO WARRANT ITS DISCONTINUANCE MAJOR TOXIC EFFECTS WERE PERIPHERAL NEUROPATHY(50%),LEUKOPENIA(8%),FEVER AND MYALGIAS(26%) AND ALOPECIA(40%) SEVERE CONSTIPATION OR ILEUS WAS NOT ENCOUNTERED-NAUSEA AND VOMITING WERE NOT PROMINENT COMPLAINTS |
| Dose amount | 3.0 MG |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | SQ M BODY SURFACE |
| Dose expression | DOSE |
| Gender | GIVEN TO BOTH SEXES |