Experiment 1073067
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | INTRATHECAL |
| Organism | Maytenus buchananii (CELASTRACEAE) |
| Citation | GHETTI,B:. (1979). INDUCTION OF NEUROFIBRILLARY DEGENERATION FOLLOWING TREATMENT WITH MAYTANSINE IN VIVO.. 163() |
| Amount utilized | |
| Compound isolated | |
| Disease | ANIMALS STUDIED BY LIGHT MICROSCOPY AND ELECTRON MICROSCOPY URINARY RETENTION,REDUCTION IN MOTOR ACTIVITY,WEAKNESS OF LIMBS AND LATER GENERALIZED HYPOTONIA SYMPTOMS APPEARED WITHIN FIRST 24-36 HOURS AND PROGRESSED RAPIDLY HISTOLOGY REVEALED MARKED CLUMPING OF THE NISSL SUBSTANCE AND DECREASE IN NUMBER OF MICROTUBLES IN THE PERIKARYON |
| Dose amount | 50.0 MCG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | RABBIT |
| Per unit | ANIMAL |
| Dose expression | DOSE |
| Gender | GIVEN TO BOTH SEXES |